来宝网 2011/7/12点击3296次
二氢睾酮（dihydrotestosteroneC19H30O2）。亦称17β－羟基-5α-雄[甾]烷-3-酮、5α－二氢**、5α－DHT、或**酮（stanorone）。是**的双键在5α处被还原的甾醇。对附属腺（前列腺、精囊腺等），起着所谓的真的雄性激素的作用。在附属性腺的细胞中存在着形成该甾醇的5α-氢化酶。该甾醇和受体蛋白质在细胞内结合成的复合体进入附属腺的细胞核中，促进新的蛋白质合成。显示出比**稍强的雄性激素作用。5β-体虽在肝脏、鸡冠等中以**形态存在，但是没有雄性激素的作用。5α－二氢**由于3α-羟基甾醇脱氢酶的作用而代谢成为5α-**-3α－17β-二醇排出体外。
Sigma相关产品资料:
Sigma A8380 5α-Androstan-17β-ol-3-one ≥97.5%
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Synonym: |
17β-Hydroxy-5α-androstan-3-one'' 4''5α-Dihydrotestosterone'' Androstanolone'' Stanolone |
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CAS Number: |
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Linear Formula: |
C19H30O2 |
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Molecular Weight: |
290.44 |
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Beilstein Registry Number: |
2056371 |
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EC Number: |
208-307-3 |
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MDL number: |
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PubChem Substance ID: |
Description
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Biochem/physiol Actions |
Anabolic steroid. Testosterone secreted by the testis is converted to dihydrotestosterone in the target tissues where it appears to mediate many of the biological actions of testosterone. Androgens direct the development of the male phenotype during embryogenesis and at puberty. |
性质
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assay |
≥97.5% |
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drug control |
USDEA Schedule III; Home Office Schedule 4.2; regulated under CDSA - not available from Sigma-Aldrich Canada |
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Gene Information |
human ... AR(367)'' ESR1(2099)'' PGR(5241)'' SERPINA6(866)'' SHBG(6462) |
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rat ... Ar(24208)'' Esr1(24890)'' Nr |
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mouse ... Esr1(13982) |
安全性
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Personal Protective Equipment |
Eyeshields'' full-face particle respirator type N100 (US)'' Gloves'' respirator cartridge type N100 (US)'' type P1 (EN143) respirator filter'' type P3 (EN 143) respirator cartridges |
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Hazard Codes |
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Risk Statements |
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Safety Statements |
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WGK Germany |
3 |
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RTECS |
BV8052000 |
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品名 |
产地 |
货号 |
规格 |
单价 |
备注 |
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DHT/二氢睾酮/Stanolone/双氢睾酮/Androstanolone |
Sigma |
A8380 |
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640 |
现货 |
