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Actinomycin D 放线菌素D
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英文名:Dactinomycin, Actinomycin D, ACTD
中文名: 更生霉素, 放线菌素D
CAS: 50-76-0
说明:放线菌素D（Dactinomycin D）又称更生霉素，分子中含有一个苯氧环结构，通过它连接两个等位的环状肽链。此肽链可与DNA分子的脱氧鸟嘌呤发挥特异性相互作用，使dactinomycin D嵌入DNA双螺旋的小沟中，与DNA形成复合体，阻碍RNA多聚酶的功能，抑制RNA的合成，特别是mRNA的合成。属于周期非特异性药物。一次静脉注射给药后，很快从血浆消除，多数药物以原形经胆汁和尿液排出。抗瘤谱较窄，用于肾母细胞瘤、绒毛膜上皮癌、横纹肌肉瘤和神经母细胞瘤等。
Sigma相关产品资料：
Sigma A1410 Actinomycin D from Streptomyces sp.,
~98% (HPLC)
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Synonym: |
Actinomycin C1, Actinomycin IV, Dactinomycin |
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CAS Number: |
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Linear Formula: |
C62H86N12O16 |
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Molecular Weight: |
1255.42 |
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Beilstein Registry Number: |
605235 |
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EC Number: |
200-063-6 |
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MDL number: |
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PubChem Substance ID: |
Description
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Biochem/physiol Actions |
An antineoplastic antibiotic that inhibits cell proliferation by forming a stable complex with DNA and blocking the movement of RNA polymerase which interferes with DNA-dependent RNA synthesis. Induces apoptosis. Potent antitumor agent. For cell culture applications, actinomycin D is used as a selection agent and is used in banding techniques to differentiate between different regions of chromosomes. |
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Caution |
Hygroscopic and light sensitive. |
性质
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biological source |
from Streptomyces sp. |
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assay |
~98% (HPLC) |
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form |
powder |
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color |
red, powder |
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red to orange |
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mp |
251-253 |
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solubility |
DMSO: 1 mg/mL |
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ethanol: soluble |
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storage temp. |
2 |
安全性
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Personal Protective Equipment |
Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
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Hazard Codes |
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Risk Statements |
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Safety Statements |
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RIDADR |
UN3462 6.1/PG 2 |
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WGK Germany |
3 |
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RTECS |
AU1575000 |
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品名 |
产地 |
货号 |
规格 |
单价 |
备注 |
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Actinomycin D/放线菌素D/更生霉素 |
Sigma |
A1410 |
5MG |
询价 |
现货 |
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Actinomycin D/放线菌素D/更生霉素 |
Sigma |
A55051 |
5MG |
询价 |
现货 |
