来宝网 2010/12/30点击2188次
中文名：地西他滨；5-氮杂-2’-脱氧胞嘧啶核苷
英文名: 5-Aza-2′-deoxycytidine; 2′-Deoxy-5-azacytidine；Decitabine
CAS:2353-33-5
产品作用：
地西他滨作为特异的 DNA甲基化转移酶抑制剂，可逆转 DNA的甲基化过程，诱导肿瘤细胞向正常细胞分化或诱导肿瘤细胞凋亡。在肿瘤细胞内，地西他滨被脱氧胞苷激酶磷酸化，以磷酸盐的形式与 DNA掺合。高浓度的地西他滨掺合可抑制 DNA合成诱导细胞死亡，发挥其细胞毒作用;低浓度的地西他滨掺合可替代肿瘤细胞内的胞嘧啶与 DNA甲基化转移酶共价结合，使 DNA甲基化转移酶失活但不会导致细胞死亡。
地西他滨的适应证为骨髓增生异常综合征，另有研究，其对镰状细胞性贫血、髓性细胞白血病以及一些实体瘤也有疗效。
外观为：白色或类白色结晶粉末
SIGMA相关资料:
Sigma A3656 5-Aza-2′-deoxycytidine
≥97%
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Synonym: |
2′-Deoxy-5-azacytidine'' Decitabine'' 4-Amino-1-(2-deoxy-β-D-ribofuranosyl)-1''3''5-triazin-2(1H)-one |
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CAS Number: |
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Linear Formula: |
C8H12N4O4 |
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Molecular Weight: |
228.21 |
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Beilstein Registry Number: |
617982 |
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EC Number: |
219-089-4 |
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MDL number: |
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PubChem Substance ID: |
Description
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Frequently Asked Questions |
Live Chat and Frequently Asked Questions |
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General description |
Decitabine is an epigenetic modifier that inhibits DNA methyltransferase activity which results in DNA demethylation (hypomethylation) and gene activation by remodeling “opening” chromatin. Genes are synergistically reactivated when demethylation is combined with histone hyperacetylation. |
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Biochem/physiol Actions |
5′-Azadeoxycytidine causes DNA demethylation or hemi-demethylation. DNA demethylation can regulate gene expression by "opening" the chromatin structure detectable as increased nuclease sensitivity. This remodeling of chromatin structure allows transcription factors to bind to the promoter regions'' assembly of the transcription complex'' and gene expression. |
性质
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assay |
≥97% |
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solubility |
acetic acid: water (1:1): 50 mg/mL |
安全性
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Personal Protective Equipment |
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Hazard Codes |
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Risk Statements |
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Safety Statements |
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WGK Germany |
3 |
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RTECS |
XZ3012000 |
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品名 |
产地 |
货号 |
规格 |
单价 |
备注 |
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地西他滨 Decitabine |
Sigma |
A3656 |
5MG |
询价 |
现货 |
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地西他滨 Decitabine |
Sigma |
A3656 |
10MG |
询价 |
现货 |
