EDQM标准物质是经过专门筛选的，并由欧洲药典委员会对检验后的标准物质进行确认。根据标准物质的用途（如鉴别、纯度检查、含量测定），可能会作为国际协作研究的项目。根据ISO导则34基本原则建立与分发标准物质。这些标准物质可在鉴别试验、有关物质检查、含量测定等药物分析中用作对照品，也可用于仪器的校正。
EDQM被指定为WHO抗生素国际标准品的协作标定中心
Y0000818 Clotrimazole impurity E 10 mg
Y0000849 Clotrimazole for peak identification 1 mg
C2450000 Cloxacillin sodium 125 mg
C2460000 Clozapine 60 mg
Y0000758 Clozapine for peak identification 0.41 mg
Y0000162 Cocaine hydrochloride - reference spectrum n/a
C2480000 Cocoyl caprylocaprate 40 mg
Y0000722 Codeine - * narc 20 mg
C2500000 Codeine - reference spectrum n/a
Y0000334 Codeine impurity A (methylcodeine) 10 mg
C2500100 Codeine hydrochloride dihydrate - reference spectrum n/a
C2510000 Codergocrine mesilate 60 mg
C2580000 Colchicine 50 mg
Y0000209 Colchicine for system suitability 50 mg
Y0000374 Colestyramine 10 mg
C2600000 Colistimethate sodium 100 mg
Y0000277 Colistin sulphate 25 mg
C2700000 Colistin sulphate for microbiological assay 25 mg
C2725000 Copovidone - reference spectrum n/a
C2800000 Cortisone acetate 250 mg
Y0000438 Coumarin 80 mg
C2900000 Cotton wool. standard for neps 1000 mg
C2950000 Crospovidone - reference spectrum n/a
C2970000 Crotamiton 100 mg
C2970005 Crotamiton impurity A 30 mg
C3000000 Cyanocobalamin 20 mg
C3090000 Cyclizine hydrochloride 50 mg
Y0000886 Cyclizine impurity A 15 mg
Y0000887 Cyclizine impurity B 10 mg
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