xCELLigence - Label-Free Cellular Analysis

Cambridge Bioscience, in collaboration with ACEA Biosciences offers the impedance-based xCELLigence and iCELLigence systems. These systems monitor cellular processes such as cell proliferation, cytotoxicity, adhesion, viability, invasion, functional signalling and migration in real time without the incorporation of labels or reporters.

xCELLigence & iCELLigence Technology
The xCELLigence and iCELLigence systems utilise electronic cell sensor array technology by measuring electrical impedance across micro-electrodes embedded in the bottom of tissue culture E-Plates.

iCELLigence

iCELLigence Special Offer
Until the 23rd December 2013, for every complete iCELLigence system ordered, 24 L8 E-plates compatible with the instrument, with a value of ￡488, will be provided free of charge. Please quote the discount code ICELLFREE to reclaim this offer. Terms and conditions apply.
To find out more, pleaseClick Here

Features & Benefits of the xCELLigence & iCELLigence Systems
The xCELLigence and iCELLigence systems offer:
? Label-free monitoring
No reporters are required with these systems enabling the direct use of primary and disease relevant cells without any biochemical modifications
? Real-time, accurate & dynamic monitoring
These systems can monitor and record an entire experiment without losing any data in real-time. This method:
- Enables discovery not possible with end point analysis
- Focuses assay development and optimisation
- Improves attrition rates
- Identifies potential events (risks or adverse events) not possible with other technologies
? Continuous quality control
This provides data quality assurance on cell characteristics
? Quantitative information regarding the biological status of the cells is produced
This information includes cell number, viability and morphology
? Non-invasive measurement
These systems enables the re-use of cells in long-term/complementary assays
? Physiologically relevant
These systems are designed to monitor live cells in tissue culture in a physiologically relevant environment without fixation or labelling
? Wide ranging applications
A wide range of cell-based assays can be performed on these systems for both high throughput screening and laboratory research
? Widely referenced
Over 400 papers have been published in peer review journals in regard to these systems with a wide range of applications.

Comparing xCELLigence & iCELLigence Against Traditional End-Point Assays
The xCELLigence and iCELLigence systems offer clear and significant advantages over traditional end-point assays. By utilising label-free assays, the xCELLigence and iCELLigence systems allow physiologically relevant assays to be performed, saving time, labour and resources. The full length of an assay is also represented fully using these systems making it possible to make informed decisions with respect to the timing of certain experimental manipulations or treatments in comparison to the inflexibility of traditional end-point assays. Unlike the traditional assays, the biological status of cells can be monitored by looking at the kinetic response of the cells within an assay before or after a treatment.

Innovative Research Award - $3000 Travel Grant
In recognition of the innovative, novel and high impact research being conducted with the xCELLigence and iCELLigence RTCA systems, ACEA Biosciences is offering an Innovative Research Award. Every quarter, ACEA Biosciences will offer a travel grant to a maximum value of $3000 to researchers utlising the xCELLigence and iCELLigence RTCA systems who are both the author of a submitted abstract and presenter at either a poster or podium session attending a scientific conference. Maximum consideration will be placed on the applications that address significant scientific problems and have wide applicability.

To apply, please read the application guide and program’s Official rules which can be downloaded by Clicking Here and then send a completed application form and PDF attachment of the poster/podium presentation to grant@aceabio.com with the subject Innovative Research Award Application 2013. Award winners will be expected to participate in limited marketing activities, highlighting their research project.

Instruments Available
Cambridge Bioscience offers 6 instruments that utilise this unusual technology with variable throughput and different applications. These instruments are detailed below:
?RTCA-iCELLigence

The xCELLigence range consists of:
? RTCA-DP
? RTCA-SP
? RTCA-Cardio
? RTCA-MP
? RTCA-HT

Please click on the links below for further information.

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