来宝网移动站

Background/Target Information

                        This gene encodes a protein that is a multi-ligand type-1 receptor with similarity to the yeast carboxypeptidase Y sorting receptor Vps10 protein. The encoded protein,  a trans-Golgi network (TGN) transmembrane protein,  binds a number of unrelated ligands that participate in a wide range of cellular processes; however,  it lacks the typical features of a signalling receptor. In the TGN,  furin mediates the activation of the mature binding form. The encoded protein consists of a large luminal domain,  a single transmembrane segment and short C-terminal cytoplasmic tail. The luminal domain contains a cysteine-rich region similar to two corresponding segments in the yeast Vps10p; the cytoplasmic tail is similar to the corresponding segment of the cation-independent mannose 6-phosphate receptor and the tail also interacts with the VHS domains of GGA (Golgi-associated,  gamma-adaptin homologous,  ARF-interacting) proteins.