产品介绍
GDC-0917 (CUDC-427) is an orally available, monovalent mimetic of second mitochondrial-derived activator of caspases (Smac/DIABLO) and inhibitor of IAPs (Inhibitor of Apoptosis Proteins) with potential antineoplastic activity. Smac mimetic GDC-0917 (CUDC-427) binds to the Smac binding groove on IAPs, including the direct caspase inhibitor X chromosome-linked IAP (XIAP) and the cellular IAPs 1 and 2. This inhibits the activities of these IAPs and promotes the induction of apoptosis through apoptotic signaling pathways. IAPs are overexpressed by many cancer cell types and suppress apoptosis by binding to and inhibiting active caspases-3, -7 and -9 via their baculoviral lAP repeat (BIR) domains.
珠海市活力达生物科技有限公司是一家专业生物试剂代理商.主要代理Sigma-Aldrich, ChemieTek, Active Biochem, Enzo LifeScience, Biomyx, Chemdea, Santa Cruz, Bolegend, BD Biosciences,Progmega, R&D等美国品牌产品
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