产品介绍
VTX-2337 is a small molecule Toll-like receptor 8 (TLR8) agonist that stimulates myeloid dendritic cells, monocytes, and enhances NK cell responses. VTX-2337 selectively activates TLR8 with an EC50 of about 100 nmol/L and stimulates production of TNFa and interleukin (IL)-12 from monocytes and myeloid dendritic cells (mDC). Preclinical evaluation of VTX-2337 suggests that it may play a key role in augmenting the innate arm of the immune system and provide a valuable addition to various treatment regimens in oncology
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