性能描述
| 试剂纯度 | ≥98% (HPLC) |
| form | solid |
| color | white |
| 溶解性 | dichloromethane: soluble10 mg/mL |
| ethanol: soluble10 mg/mL |
| DMSO: soluble50 mg/mL |
| chloroform: soluble6 mg/mL |
| H2O: insoluble |
| 保存温度 | 2-8°C |
Biochem/physiol Actions
A fungal metabolite possessing potent immunosuppressive properties. It inhibits the T-cell receptor signal transduction pathway via the formation of cyclosporin A?cyclophilin complex that inhibits calcineurin (protein phosphatase 2B). Inhibits nitric oxide synthesis induced by interleukin 1α, lipopolysaccharides and TNFα. Can block cytochrome c release from mitochondria.
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