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Alternative Name:

Microcystin-RR (desmethylated

Identity:

Identity determined by MS.

Formula:

C₄₈H₇₃N₁₃O₁₂

MW:

1024.2

Purity:

≥95% (HPLC)

Appearance:

Pale powder or film.

Source/Host:

Isolated from Microcystis aeruginosa.

Solubility:

Soluble in methanol or DMSO.

Long Term Storage:

-20°C

Hazard:

HIGHLY IRRITANT.
MAY BE CARCINOGENIC.
TOXIC.

Background / Technical Information:

Microcystins are a group of cyclic heptapeptide hepatotoxins produced by a number of cyanobacterial genera. The most notable of which, and namesake, is the widespread genus Microcystis. Structurally, all microcystins consist of the generalized structure cyclo(-D-Ala¹-X²-D-MeAsp³-Y⁴-Adda⁵-D-Glu⁶-Mdha⁷-). X and Y are variable L-amino acids, D-MeAsp is D-erythro-ß-methylaspartic acid and Mdha is N-methyldehydroalanine. Adda is the cyanobacteria unique C₂₀ ß-amino acid 3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-deca-4,6-dienoic acid. Substitutions of the variable L-amino acids at positions 2 and 4 give rise to at least 21 known primary microcystin analogs and alterations in the other constituent amino acids result in more than 90 reported mycrocystins to date.