Wortmannin
MERCK相关产品资料：
681675 Wortmannin ( Wortmannin )
KY 12420
A cell-permeable, fungal metabolite that acts as a potent, selective, and irreversible inhibitor of phosphatidylinositol 3-kinase in purified preparations and cytosolic fractions (IC50 = 5 nM). Blocks the catalytic activity of PI 3-kinase without affecting the upstream signaling events. Preincubation of fibroblasts with wortmannin abolishes PDGF-mediated Ins(3,4,5)P3 formation (IC50 = 5 nM). Also blocks the metabolic effects of insulin in isolated rat adipocytes without affecting the insulin receptor tyrosine kinase activity. Inhibits MAP kinase activation induced by platelet activating factor in guinea pig neutrophils (200 - 300 nM). Also inhibits other kinases such as myosin light chain kinase (IC50 = 200 nM) and PI 4-kinase at concentrations higher than that required for inhibition of PI 3-kinase. Also blocks phospholipase D. A 10 mM (1 mg/233 µl) solution of Wortmannin (Cat. No. 681676) in DMSO is also available.
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Product number
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型号
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价格
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681675-1MG
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1 mg
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询价
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产品信息
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Form
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White to off-white solid
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Primary Target
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phosphatidylinositol-3-kinase
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Primary Target IC50
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5 nM
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Secondary target
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mlck (IC,sub>50 = 200 nM)
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Molar mass
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428.4
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Protect from Light
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Yes
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Packaged under inert gas
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Yes
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Cell permeable
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Yes
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Purity
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≥95% by HPLC
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Solubility
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DMSO or MeOH
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Chemical formula
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C23H24O8
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RTECS
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CB9641000
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CAS number
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19545-26-7
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Merck USA index
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14, 10053
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Store and ship information
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Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
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Storage
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-20°C
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Ship
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Ambient Temperature Only
Highly Toxic
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安全标示
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S Phrase
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S: 22-36/37/39-45
Do not breathe dust.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
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R Phrase
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R: 26/27/28
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