SP600125
MERCK相关产品资料：
420119 JNK Inhibitor II ( JNK Inhibitor II )
Anthra[1,9-cd]pyrazol-6(2H)-one, 1,9-pyrazoloanthrone, SP600125, SAPK Inhibitor II
A potent, cell-permeable, selective, and reversible inhibitor of c-Jun N-terminal kinase (JNK) (IC50 = 40 nM for JNK-1 and JNK-2 and 90 nM for JNK-3). The inhibition is competitive with respect to ATP. Exhibits over 300-fold greater selectivity for JNK as compared to ERK1 and p38-2 MAP kinases. Inhibits the phosphorylation of c-Jun and blocks cellular expression of IL-2, IFN-γ, TNF-α, and COX-2. Blocks IL-1-induced accumulation of phospho-Jun and induction of c-Jun transcription. A 50 mM (5 mg/454 µl) solution of JNK Inhibitor II (Cat. No. 420128) in DMSO is also available.
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Product number
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型号
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价格
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420119-5MG
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5 mg
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询价
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产品信息
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Form
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Yellowish orange solid
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Primary Target
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JNK 1, JNK 2, JNK 3
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Primary Target IC50
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40 nM, 40 nM, 90 nM
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Molar mass
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220.2
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Protect from Light
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Yes
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Packaged under inert gas
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Yes
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Cell permeable
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Yes
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Reversible
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Yes
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ATP Competitive
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Yes
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Purity
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≥98% by HPLC
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Solubility
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DMSO
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Chemical formula
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C14H8N2O
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RTECS
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CB4585000
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CAS number
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129-56-6
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Store and ship information
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Storage
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-20°C
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Ship
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Ambient Temperature Only
Standard Handling
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