SB 203580
产品说明:SB203580也写作SB 203580或SB-203580，是一种常用的p38 MAPK抑制剂。SB203580可以通透细胞，抑制p38 MAPK(p38 MAP kinase)，抑制后续MAPKAP Kinase-2和MAPKAP Kinase-3的激活。通过抑制p38 MAPK，SB203580可以有效抑制一些炎症因子(如IL-1β、TNF-α)诱导的部分信号转导。SB203580选择性抑制p38 MAPK，IC50为600 nM；对于JNK/SAPK和p44/42 MAPK(即Erk1/2)无显著的抑制作用，IC50仅为100 μM。
SB203580分子量为377.43，分子式为C21H16N3FOS，CAS Number：152121-47-6。
MERCK相关产品资料：
559389 SB 203580 ( SB 203580 )
4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole
A highly specific, potent, cell-permeable, selective, reversible, and ATP-competitive inhibitor of p38 MAP kinase (IC50 = 34 nM in vitro, 600 nM in cells). Does not significantly inhibit the JNK and p42 MAP kinase at 100 µM. Inhibits IL-1 and TNF-α production from LPS-stimulated human monocytes and the human monocyte cell line THP-1 (IC50 = 50-100 nM). Inhibits bone morphogenetic protein-2-induced neurite outgrowth in PC12 cells. Also inhibits platelet aggregation caused by collagen (IC50 = 0.2-1.0 µM) or the thromboxane analog U-46619 (Cat. No. 538944). A 1 mg/ml solution of SB 203580 (Cat. No. 559398) in anhydrous DMSO is also available.
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Product number
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型号
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价格
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备注
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559389-1MG
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1 mg
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询价
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现货
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产品信息
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Form
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Thin film
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Primary Target
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P38MAPK
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Primary Target IC50
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34 nM
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Secondary target
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THP-1 (IC50 = 500-100 nM)
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Molar mass
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377.4
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Protect from Light
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Yes
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Cell permeable
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Yes
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Purity
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≥98% by HPLC
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Solubility
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DMSO
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Chemical formula
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C21H16N3OSF
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CAS number
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152121-47-6
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Store and ship information
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Storage
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-20°C
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Ship
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Ambient Temperature Only
Irritant
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安全标示
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S Phrase
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S: 26-36-45
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
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R Phrase
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R: 36/37/38
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