ATM(R2443Q)小鼠单抗

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ATM(R2443Q)小鼠单抗
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  • 参考报价：4800 产地：湖北 品牌：NewEastBio 型号：ATM(R2443Q) 更新时间：2023/5/11

ATM(R2443Q) 小鼠单抗

货号:   26143
基因符号:   ATM
描述:   Anti-ATM(R2443Q) Mouse Monoclonal Antibody
背景介绍:   Ataxia telangiectasia mutated (ATM) is a serine/threonine protein kinase that is recruited and activated by DNA double-strand breaks. It phosphorylates several key proteins that initiate activation of the DNA damage checkpoint, leading to cell cycle arrest, DNA repair or apoptosis. Activity of ATM protein is under tight control, and mutation of ATM can cause disease such as Ataxia telangiectasia (AT) and cancers.
免疫原:    A synthetic peptide from the internal region of ATM, which includes the mutation of R2443Q, human origin
经过测试的应用:   ELISA, WB, IHC
推荐稀释比:   
ELISA: 1: 1000-1: 5000
WB: 1: 100-1: 1000
IHC: 1: 50-1: 100
浓度:   1 mg/ml
宿主:   Mouse
形式:   Liquid
克隆性:   Monoclonal
亚型:   IgG
纯度:   Purified from ascites
防腐剂: No
成分:   PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol
种属反应性:   Recognizes ATM(R2443Q), but not wild type ATM protein from vertebrates
储存条件:    Store at -20°C. Avoid repeated freezing and thawing

蛋白质印迹:   

Western blot analysis of recombinant ATM(R2443Q) and wildtype proteins.

Purified His-tagged ATM(R2443Q) protein (amino acids 2400-3056, lane 2) and corresponding wild type protein (lane 1) were blotted with Anti-ATM(R2443Q) mouse monoclonal antibody (Cat. #26143).


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