光遗传系统..

 采用光遗传进行点燃癫痫研究

                                                                                                                                                                                                                                                                        

 Cortical EEG ａnd hippocampal depth electrode activity with prefrontal cortex glutamate changes during kindling stimulation with blue (445 nm) light in a transgenic mouse from Jackson Laboratory expressing channelrhodopsin.

Light pulses (20 Hz, 10% duty cycle, 600 mA) were delivered for 20 seconds. The blue LED power measured prior to implant was 130 mW/mm2 .
光遗传改变睡眠状态

Application of 40 Hz stim frequency (10% duty cycle, 600 mA) 10 seconds ON, 10 seconds OFF periods for one hour intervals (blue bars) results in increased power in the Gamma frequency (25-50 Hz) range ａnd decreased NREM sleep by an average of 42 percent during time when stim was applied.

软件
 

癫痫分析软件                                                                                          动物活动视频跟踪分析， 活动实时跟踪记录

自动癫痫发作识别、热密度图谱、光谱图、时间分析、功效分析

癫痫统计： 平均持续时间、 癫痫发作间隔时间、峰值频率等                       

 

睡眠分析软件

三种睡眠评分手段： 手动、簇、阈值评分

实时睡眠图（hypnograms）、波谱图、热点图辅助评判睡眠状态。功效分析、峰值频率分析

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