BCL10 Polyclonal Antibody | A0191_BCL10.pdf |
Catalog No: A0191 | Species: Rabbit | |
Gene ID: 8915 | Isotype: IgG | |
Swiss Prot: O95999 | Purity: Affinity purification | |
Applications: WB IHC | Cross-Reactivity: H M | |
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| 200ug | ＄380 | Ship in 5 business days | Adding to the cart | | |
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Alt. Names
CLAP; mE10; CIPER; c-E10; CARMEN;
Recommended Dilutions
WB: 1:500-1:2000
IHC: 1:50-1:200
Products data
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Western blot analysis of extracts of Mouse ovary, using BCL10 antibody. | | |
Immunogen
Recombinant protein of human BCL10
Storage
Store at -20oC or -80oC. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Background
This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.