The Xpansion bioreactor system represents the best solution for process industrialization to drive cell therapies to market faster, as it delivers better patient safety and GMP compliance. The Xpansion system is especially developed for fragile adherent cell culture applications, such as stem cell cultures. Because of its compact structure and large cell growth surface area (up to 115,000cm2, equivalent to 18CS10), the Xpansion bioreactor enables production of large amounts of cells in a process easily adapted from traditional T-flask or stacked tray methods with the advantage of cell culture parameter controls.

The 2-D multiplate design of the Xpansion bioreactors offers the same cell environment as standard multitray technology but adds the benefit of a closed system for increased protection from potential contamination. In addition, critical cell culture parameters do not change using Xpansion systems, successfully mitigating risk during process scale-up for large clinical studies. All of this enables easy transfer from existing technologies to Xpansion systems at any stage of a clinical study. Moreover, Xpansion bioreactors offer quick scale-up to process design for flexibility and speed in both upstream and downstream processing. By also dramatically reducing the number of operations needed, safety is maximized and cost of goods can successfully be reduced by up to 40%.

咨询、索取咨询请致电客服电话400-650-8506

Benefits

Integrity Xpansion Bioreactor Highlights and Benefits

• GMP compliant
• Completely single use closed bioreactor from vessel to sensor for sterility and contamination risk reduction
• Multiplate 2-D cell culture design enables easy industrialization of the traditional multitray stacks
• Cell culture reproducibility and traceability by monitoring culture parameters (pH, DO, temperature) and real time controls
• Upstream and downstream processing flexibility and speed: reduction of numbers of operations, complexity and risks related to operations (e.g. seeding, medium exchange, harvest)
• Scalable to follow process development, as needed
• Designed for use in a completely closed system from seeding to harvest