| Catalogue Number |
PRO-862 |
| Synonyms |
MURR1, C2orf5, COMMD1, Copper Metabolism Domain Containing 1, MGC27155. |
| Introduction |
COMMD1 is accountable for inhibition of TNF-induced NFκB p50 and n facilitats of biliary copper excretion within hepatocytes. High expression of COMMD1 is localized in liver tissue, with lower expressions in lung, heart, kidney and brain tissue. COMMD1 interacts directly with COMMD6 and ATP7B, and indirectly with IκB-β and COMMD7. |
| Description |
COMMD1 Recombinant Human produced in E.Coli is a single, non-glycosylated polypeptide chain containing 210 amino acids (1-190 a.a.) and having a molecular mass of 23.3 kDa. The COMMD1 is fused to 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques. |
| Source |
Escherichia Coli. |
| Physical Appearance |
Sterile filtered colorless solution. |
| Formulation |
COMMD1 Human solution containing 20mM Trsi pH-8, 0.1M NaCl& 20% glycerol. |
| Stability |
COMMD1 Human although stable at 4°C for 1 week, should be stored desiccated below -18°C.
Please prevent freeze thaw cycles. |
| Purity |
Greater than 90.0% as determined by SDS-PAGE. |
| Amino acid sequence |
MGSSHHHHHH SSGLVPRGSH MAAGELEGGK PLSGLLNALA QDTFHGYPGI TEELLRSQLY PEVPPEEFRP FLAKMRGILK SIASADMDFN
QLEAFLTAQT KKQGGITSDQ AAVISKFWKS HKTKIRESLM NQSRWNSGLR GLSWRVDGKS QSRHSAQIHT PVAIIELELG KYGQESEFLC LEFDEVKVNQ ILKTLSEVEE SISTLISQPN. |
| Usage |
ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals. |