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T0901317
Cayman Chemical Item Number 71810
(CAS 293754-55-9)
T0901317 (CAS 293754-55-9)
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- Nuclear Receptors (80)
- Atherosclerosis (323)
|
Description
The Liver X Receptors (LXRα and LXRβ) are nuclear hormone receptors whose native ligands are oxysterols, such as 22(R)-hydroxycholesterol. The LXRs regulate the oxysterol-induced expression of cholesterol 7α-hydroxylase, the rate limiting enzyme of classic bile acid synthesis. T0901317 is a potent and selective agonist for both LXRα and LXRβ, with an EC50 of about 50 nM.1 T0901317 acting through LXR and in concert with its RXR heterodimerization partner induces the expression of the ABCA1 reverse cholesterol transporter. This acts to increase the efflux of cholesterol from enterocytes and thus inhibit the overall absorption of cholesterol.
1 Repa, J.J., Turley, S.D., Lobaccaro, J.A., et al. Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers. Science 289 1524-1529 (2000).
| Formal Name |
N-?(2,?2,?2-?trifluoroethyl)-?N-?[4-?[2,?2,?2-?trifluoro-?1-?hydroxy-?1-?(trifluoromethyl)ethyl]phenyl]-?benzenesulfonamide |
| CAS Number |
293754-55-9 |
| Molecular Formula |
C17H12F9NO3S |
| Formula Weight |
481.3 |
| Formulation |
A crystalline solid |
| Purity |
>98% |
| λmax |
227, 265, 272 nm |
| Stability |
1 year |
| Storage |
-20°C |
| Shipping |
Wet ice in continental US; may vary elsewhere |
| SMILES |
O=S(=O)?(c1ccccc1)?N(CC(F)?(F)?F)?c1ccc(cc1)?C(O)?(C(F)?(F)?F)?C(F)?(F)?F |
Background Reading
Repa, J.J., Turley, S.D., Lobaccaro, J.A., et al. Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers. Science 289 1524-1529 (2000).