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抗体信息如下：
Primary Antibodies
Caspase-14 Antibody
Background
Caspases are a family of cysteine proteases that can be divided into apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. Members of this subfamily include caspase-1, -4, -5, and -12 and can activate proinflammatory cytokines such as IL-1b and IL-18. Caspase-14 is highly expressed in embryonic but not adult tissues. It is processed and activated by caspase 8 and caspase 10 in vitro, and by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of this caspase may be involved in the keratinocyte terminal differentiation, which is important for the formation of the skin barrier.
Additional Names
Caspase-14, Mini-interleukin-1 converting enzyme, Mini-ICE, MICE
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Description
Left: Western blot analysis of caspase-14 in Jurkat cell lysate in the (A) absence or (B) presence of blocking peptide with caspase-14 antibody at 1 μg/ml.
Below: Immunohistochemistry of caspase-14 in human liver tissue with caspase-14 antibody at 2.5 μg/ml. |
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Other Product Images
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Source
Caspase-14 antibody was raised against a 16 amino acid peptide from near the carboxy-terminus of human caspase-14.
Purification
Affinity chromatography purified via peptide column
Clonality / Clone
This is a polyclonal antibody.
Host
Caspase-14 antibody was raised in rabbit.
Please use anti-rabbit secondary antibodies.
Application
Caspase-14 antibody can be used for the detection of caspase-14 by Western blot at 1 μg/ml.
Tested Application
E, WB, IHC
Buffer
Antibody is supplied in PBS containing 0.02% sodium azide.
Blocking Peptide
Cat.No. 2505P - Livin Peptide
Storage
Caspase-14 antibody can be stored at 4?C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Positive Control
- Cat. No. 1205 - Jurkat Cell Lysate
- Cat. No. 1304 - Human Liver Tissue Lysate
Species Reactivity
H, M, R
Protein GI Number
6753280
Protein Accession Number
NP_033939
Short Description
a novel caspase
This product belongs to the following categories:
- Antibodies
- Polyclonal Antibodies
- Apoptosis Antibodies
Related Products
- Caspase-14 Peptide
(Catalog No. 2509P).
- Jurkat Cell Slide
(Catalog No. 17-005).
- Jurkat Lysate
(Catalog No. 1205).
- Liver Lysate
(Catalog No. 1304).
- Liver Tissue Slide (Normal)
(Catalog No. 10-201).
References
- Martinon F and Tschopp J. Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases. Cell 2004; 117:561-74.
- Zhivotovsky B and Orrenius S. Caspase-2 function in response to DNA damage. Biochim. Biophys. Res. Comm. 2005; 331:859-67.
- Kuida K, Lippke JA, Ku G, et al. Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme. Science 1995; 267:2000-3.
- Gracie JA, Robertson SE, and McInnes IB. Interleukin-18. J. Leukoc. Biol. 2003; 73:213-224.
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