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抗体信息如下：
Primary Antibodies
DRAK2 Antibody
Background
Apoptosis is mediated by death domain containing adapter molecules and a caspase family of proteases. Certain serine/threonine protein kinases, such as ASK-1 and RIP, are mediators of apoptosis. Two novel serine/threonine kinases that induce apoptosis were recently identified and designated DRAK1 and DRAK2 (for DAP kinase-related apoptosis-inducing protein kinases) (1). DRAKs contain an N-terminal kinase domain and a C-terminal regulation domain. Overexpression of DRAK2 induces apoptosis. DRAKs have high sequence homology to DAP and ZIP kinases, and they represent a novel family of serine/threonine kinases, which mediates apoptosis through their catalytic activities. DRAK2 is located in nucleus and the messenger RNA was ubiquitously expressed in human tissues (1).
Additional Names
DRAK2 (CT), DRAK2
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Description
Left: Western blot analysis of DRAK2 in Jurkat (1,3) and Raji (2,4) cell lysate in the absence (1,2) or presence (3,4) of blocking peptide with DRAK2 antibody at 1:500 dilution.
Below: Immunocytochemistry of DRAK2 in Jurkat cells with DRAK2 antibody at 10 μg/ml. |
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Other Product Images
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Source
DRAK2 antibody was raised against a peptide corresponding to amino acids 351 to 365 of human DRAK2.
Purification
Ion exchange chromatography purified
Clonality / Clone
This is a polyclonal antibody.
Host
DRAK2 antibody was raised in rabbit.
Please use anti-rabbit secondary antibodies.
Immunogen
Human DRAK2 (C-Terminus) Peptide (Cat. No. 2149P)
Application
DRAK2 antibody can be used for detection of DRAK2 by Western blot at 1:500 to 1:1000 dilution. An approximately 45 kDa band can be detected. It has no cross responses to DAP or ZIP kinases. The approximately 70 kDa band is probably non-related to DRAK2 although it is peptide blockable.
Tested Application
E, WB, ICC
Buffer
Antibody is supplied in PBS containing 0.02% sodium azide.
Blocking Peptide
Cat. No. 2149P - DRAK2 Peptide
Storage
DRAK2 antibody can be stored at 4?C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Positive Control
- Cat. No. 1205 - Jurkat Cell Lysate
Species Reactivity
H
Protein GI Number
3834355
Protein Accession Number
AB011421
Short Description
(CT) DAPK Related Apoptosis-inducing Kinase
This product belongs to the following categories:
- Antibodies
- Polyclonal Antibodies
- Apoptosis Antibodies
- Autophagy Antibodies
Related Products
- DRAK2 Peptide
(Catalog No. 2149P).
- Jurkat Cell Slide
(Catalog No. 17-005).
- Jurkat Lysate
(Catalog No. 1205).
References
- Sanjo H, Kawai T, Akira S. DRAKs, novel serine/threonine kinases related to death-associated protein kinase that trigger apoptosis. J Biol Chem 1998;273:29066-71 (RD1299)
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