北京乐博生物科技有限公司是美国ProSci授权一级代理商，供应其全线产品涵盖了细胞凋亡、信号传导、肿瘤、免疫、细胞生物、神经生物和传染病等领域。产品应用于ELISA、WB、IHC、FACS等，为您的实验提供多样的检测手段，产品应用文献发表在PNAS、Cell research、Blood……使用广泛。
抗体信息如下
Primary Antibodies
NALP3 Antibody
Background
NALP3, a member of Nod-like receptors, has a crucial role in inflammation and immunity and may be a proximal sensor of cellular stress and danger signals. NALP3 forms a caspase-1 activating molecular complex termed the inflammasome. The inflammasome allows activation of IL-1b, the key player of the inflammation and fever. NALP3 gene encodes a pyrin like protein which contains a pyrin domain, a nucleotide binding site (NBS) domain, and a leucine rich repeat (LRR) motif. NALP3 protein interacts with apoptosis associated speck like protein containing a CARD and may function as an inducer of apoptosis and an activator of NF-kB signaling. Defects in NALP3 have been associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID).
Additional Names
NALP3, LRR and PYD domains-containing protein 3, CIAS1, FCAS, Cryopyrin
 |
Description
Left: Western blot analysis of NALP3 in K562 cell lysate with NALP3 antibody at 1 μg/ml (A) in the absence and (B) in the presence of blocking peptide.
Below: Immunofluorescence of NALP3 in K562 cells with NALP3 antibody at 20 μg/ml. |
| |
Other Product Images
 |
Source
NALP3 antibody was raised against a 16 amino acid peptide from near the amino terminus of human NALP3.
Purification
Affinity chromatography purified via peptide column
Clonality / Clone
This is a polyclonal antibody.
Host
NALP3 antibody was raised in rabbit.
Please use anti-rabbit secondary antibodies.
Application
NALP3 antibody can be used for detection of NALP3 by Western blot at 1 - 2 μg/ml.
Tested Application
E, WB, IF
Buffer
Antibody is supplied in PBS containing 0.02% sodium azide.
Blocking Peptide
Cat.No. 5447P - NALP3 Peptide
Storage
NALP3 antibody can be stored at 4?C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Positive Control
- Cat. No. 1204 - K562 Cell Lysate
Species Reactivity
H, M
Protein GI Number
34878690
Protein Accession Number
NP_899632
Short Description
LRR and PYD domains-containing protein 3
This product belongs to the following categories:
- Antibodies
- Polyclonal Antibodies
- Apoptosis Antibodies
References
- Chamaillard M, Girardin SE, Viala J, et al. Nods, Nalps and Naip: intracellular regulators of bacterial-induced inflammation. Cell. Microbiol. 2003; 5:581-92.
- O'Connor W Jr., Hartin JA, Zhu X, et al. Cutting edge: CIAS1/cryopyrin/PYPAF1/NALP3/CATERPILLER 1.1 is an inducible inflammatory mediator with NF-kappa B suppressive properties. J. Immunol. 2003; 171:6329-33.
- Kanneganti TD, Ozoren N, Body-Malapal M, et al. Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp. Nature 2006; 440:233-6.
- Agostini L, Martinon F, Burns K, et al. NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder. Immunity 2004; 20:319-25.
更多现货抗体欢迎咨询乐博生物：010-59564854