产品介绍
Ionomycin calcium salt from Streptomyces conglobatus(离子霉素钙盐)
powder, ≥98% (HPLC)
别名:离子霉素钙盐;链霉菌属载体;Ionomycin Calcium Salt
CAS Number 56092-82-1
Empirical Formula (Hill Notation) C41H70CaO9
Molecular Weight 747.07
中文描述
本Ionomycin为Ionomycin calcium,是一种常用的钙离子载体,可以高度选择性结合钙离子(Ca2+> Mg2+>>Ba2+),并且比A23187的效果要好很多。Ionomycin在pH7.0和9.5直接可以结合钙离子,并产生较强的紫外吸收。
Ionomycin常用于转运钙离子穿过各种生物膜。加入Ionomycin最常用于提高细胞内的钙离子水平。通过提高细胞内钙离子水平,Ionomycin可以诱导神经细胞发生细胞凋亡,可以诱导一些细胞产生cell cycle arrest,也可以产生多种由于细胞内钙离子水平升高而产生的其它生物功能。
注意事项:
Ionomycin对人体有害,请注意适当防护。
Ionomycin在4℃、冰浴等较低温度情况下会凝固而粘在离心管管底、管壁或管盖内,可以20-25℃水浴温育片刻至全部融解后使用。
品牌,规格,价格,现货提供:
名称 | 品牌 | 货号 | 规格 | 价格 |
Ionomycin calcium salt | sigma | I0634 | 1MG | 1540 |
Ionomycin calcium salt | sigma | I0634 | 5mg | 6866 |
assay | ≥98% (HPLC) |
form | powder |
storage condition | desiccated |
| protect from light |
color | white to off-white |
solubility | DMSO: soluble10 mg/mL |
| ethanol: soluble |
storage temp. | 2-8°C |
Preparation Note
Store ionomycin in powder form desiccated and protected from light at 2-8 °C. Under these conditions the product is stable for 3 years. Store stock solutions in ethanol or DMSO at -20 °C, protected from light. Under these conditions the stock solutions are stable for several months. For short term use (up to 6 weeks) the stock solutions maybe stored at 2-8 °C protected from light.
Biochem/physiol Actions
Ca2+ ionophore that is more effective than A23187 as a mobile ion carrier for Ca2+; non-fluorescent; used to study Ca2+ transport across biological membranes; induces apoptotic degeneration of embryonic cortical neurons.