产品介绍
产品概述
Ugo Basile 灌流系统是一个半自动化仪器，用于研究突触体样品中的神经递质的释放。该系统最早源于Raiteri实验室，约有200报刊文献刊登了这项技术的发现。
产品参数
电源： | 115 或230 V, 50/60 Hz, 100 W max |
工作温度： | 15° - 30° C |
声级： | < 70 dB (A) |
尺寸 |
电子单元： | 38 (w) x 30 (d) x 13 (h) cm |
组合浴腔： | 46 (w) x 28 (d) x 60 (h) cm |
总重： | 34.00 Kg |
毛重： | 45.00 Kg approx |
包装尺寸: | 1号箱 80x60x44 cm 2号箱 66x50x63 cm |
产品特性
特征 | 优点 |
12腔可同时运行 | 高效高产 |
可用于突触体和大脑薄片 | 适用于多种实验 |
产品应用
Method Paper:
- M. Raiteri, F. Angelini, G. Levi: “A simple apparatus for studying the release of neurotransmitters from synaptosomes“ Eur. J. Pharmacol. 25: 411-414, 1974
Papers quoting 14900:
- A. Pittaluga et alia: "Effects of the neoclerodane Hardwickiic acid on the presynaptic opioid receptors which modulate noradrenaline and dopamine release in mouse central nervous system" Neurochemistry Intl. 62 (4): 354-359, 2013
- S. Zucchini et alia: “Increased excitability in tat-transgenic mice: Role of tat in HIV-related neurological disorders” Neurobiology of Disease: available onlyne 2013
- F. Giribaldi et alia: “Group I metabotropic glutamate autoreceptors induce abnormal glutamate exocytosis in a mouse model of amyotrophic lateral sclerosis” Neuropharmacology 66: 253-263, 2013
- J. Marrocco et alia: “Anxiety-Like Behavior of Prenatally Stressed Rats Is Associated with a Selective Reduction of Glutamate Release in the Ventral Hippocampus” J. neuroscience 32 (48): 17143-17154, 2012
- C. Romei et alia: “The GABAB receptor antagonists CGP35348 and CGP52432 inhibit glycine exocytosis: Study with GABAB1- and GABAB2-deficient mice” Pharmacological Res. 61: 547-552, 2010
- M. Grilli et alia: “Specific Inhibitory Effect of Amyloid-β on Presynaptic Muscarinic Receptor Subtypes Modulating Neurotransmitter Release in the Rat Nucleus Accumbens” Neuroscience 167: 482-489, 2010
- G. Bonanno et alia: “Release of [3H]D-aspartate induced by K+-stimulation is increased in the cervical spinal cord of the wobbler mouse: a model of motor neuron disease” Neurochemistry Intl. 55: 302-306, 2009
- M. Grilli et alia: " Release-enhancing pre-synaptic muscarinic and nicotinic receptors co-exist and interact on dopaminergic nerve endings of rat nucleus accumbens" J. Neurochemistry 105 (6): 2205-2213, 2008
Additional Papers:
- A. Pittaluga et al.: “Human brain N-methyl-D-aspartate receptors regulating noradrenaline release are positively modulated by HIV-1 coat protein gp120” AIDS 10: 463-468, 1996.
- M. Di Luca et al. “Increased presynaptic protein kinase C activity and glutamate release in rats with a prenatally induced hippocampal lesion” Eur. J. Neurosci. 9: 472-479, 1997.
- M.V. Clos et al. “D2 dopamine receptors and modulation of spontaneous acetylcholine (ACh) release from rat striatal synaptosomes” Br. J. Pharmacol. 122: 286-290, 1997.
- D. Crespi et al. “Carrier-dependent and Ca2+-dependent 5-HT and dopamine release induced by (+)amphetamine, 3,4-methylendioxymethamphetamine, p-chloroamphetamine and (+)fenfluramine” Br. J. Pharmacol. 121: 1735-1743, 1997.
- E. Schlicker et al. “Effects of selective h5-HT1B (SB-216641) and h5-HT1D (BRL-15572) receptor ligands on guinea-pig and human 5-HT auto- and heteroreceptors” Naunyn-Schmiedeb. Arch. Pharmacol. 356: 321-327, 1997.
- G. Maura et al. “Glutamate release in human cerebral cortex and its modulation by 5-hydroxytryptamine acting at h 5-HT1D receptors” Br. J. Pharmacol. 123: 45-50, 1998.
- R. Sala et al. “Nerve growth factor and brain-derived neurotrophic factor increase neurotransmitter release in the rat visual cortex” Eur. J. Neurosci. 10: 2185-2191, 1998.
- M. L’Hirondel et al. “Lack of autoreceptor-mediated inhibitory control of dopamine release in striatal synaptosomes of D2 receptor-deficient mice” Brain Research 792: 253-262, 1998.
In addition, more than 300 full papers using superfused synaptosomes have been published
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