| Vascular endothelial growth factor (VEGF), also known as vascular permeability factor (VPF), is a potent mediator of both angiogenesis and vasculogenesis in human. Through alternative splicing, the single human VEGF gene produces six forms of human VEGF mRNA, which encode VEGF proteins of 121, 145, 165, 183, 189, and 206 amino acids, respectively. The 165-amino acid isoform (VEGF165) is the major gene product found in human tissue. It is the most effective angiogenic factor in the VEGF family. |
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