| Protein A is a cell wall protein derived from Staphylococcus aureus. It exhibits unique binding properties. It can bind to IgG from a variety of mammalian species and to some IgM and IgA.
It preferentially binds with the Fc region of immunoglobulins through interaction with the heavy chain. It can be conjugated to a wide variety of reporter molecules, including fluorescent dyes, enzyme markers, biotin, colloidal gold, and radioactive iodine without affecting the antibody binding site, which makes it suitable for use in immunological and other biological studies. It can also be immobilized onto solid supports such as agarose beads for total IgG-mediated extraction of proteins of interest from ascitic fluid, serum, culture supernatants, and cell extracts. |
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