产品介绍
用于进行高效的啮齿动物认知能力评估。系统提供多种标准范例，包括整套任务所必需的习惯和图形，可让动物达到特殊应用中的标准，同时收集和分析数据。所提供的标准任务范例可直接转化为已建立的猴子和人类触摸模型*。针对不同的研究需求，可对预写入的任务计划表和分析文件进行自定义。
该设备可以用来完成如下研究内容：
双选择成对/视觉辨别逆转
Two-choice Pairwise/Visual Discrimination Reversal (PD)
配对联结式学习
Paired Associate Learning (PAL)
视觉运动条件学习
Visuomotor Conditional Learning (VMCL)
5选择序列反应时
5-Choice Serial Reaction Time (5CSRT)
自行塑成
Autoshaping (AUTO)
位置辨别学习
Location Discrimination Learning(LDL)
Bussey-Saksida Rodent Touchscreen Chambers (TCN Lab, Cambridge), now available with built in electromagnetic compatibility, to ensure artifact free in-vivo recording.
This unit retains all the critical features of the standard 80614 Bussey-Saksida Mouse Touch Screen chamber. In addition, potential artifacts are eliminated at the source by shielding against electromagnetic output or by reducing the emissions at the component level on the printed circuit board. This is achieved by superior electronic engineering design and testing with a spectrum analyzer.
Faraday cage built into the sound isolation cubicle, with emc gasketed door and baffles at the air vent apertures
Low emission electronic components and p.c.b. design to reduce electromagnetic emission at source
EMC Shielded touchscreen- with no loss of sensitivity or image clarity
Experiment chamber with lid and opening door to accommodate tether
Extended reward trough opening for headstages
Optional taller sound isolation cubicles and custom modifications for electrophysiology hardware, either tethered or telemetry
The fully validated chambers described below are supported by ready to run ABET II Touch Paradigms including images, and a Whisker ? Server-based Controller for up to four test chambers. Plus, we provide the ability for the user to write their own scheduling, with web-based training. ABET II Touch software gives you ease of use, programming power, data analysis, versatility, and flexibility.
Not just a touch screen, everything about the Bussey-Saksida chamber is different
Not just another square sheet metal box, the Bussey-Saksida chamber has a unique trapezoidal wall shape to focus the animal's attention and is made from machined parts that simply slot together. The chamber can also be configured to a modular square chamber with panels, levers, lights, and a range of other operator
This equipment can run both autoshaping and a variety of operant tasks in the same chamber, with chamber configuration from autoshaping to one of the other proven paradigms in seconds Not just a touch screen, this is the ultimate modular chamber for high throughput. For example, do Visual Discrimination and Reversal in the morning and Five Choice Serial Reaction Time Task in the afternoon
To enable such a high throughput, the chamber can be taken apart and reassembled in seconds for easy cleaning
Get up and running quickly, with the Easy-Install Kit and buy proven tasks pre-programmed in ABET II Touch or get programming yourself quickly and easily with web-enabled online help from Campden Instruments and Lafayette Instrument Company
Translational research: test rodents on tasks virtually identical to tasks used to test human populations
The Bussey-Saksida Chambers and WhiskerServer ? originate from the department of Prof. Trevor Robbins, Experimental Psychology, University of Cambridge, England
TOUCH SCREEN PARADIGMS
Visit the DOWNLOADS tab for videos of these tasks.
Visual Discrimination and Reversal (VDR)
Paired Associate Learning (PAL)
Location Discrimination (LD)
Visuospatial Conditional Learning (VCL)
5-choice Serial Reaction Time Task (5-CSRT)
Trial-Unique Nonmatching-to-Location (TUNL) [rat only at this time]
Autoshaping
Extinction
VISUAL DISCRIMINATION AND REVERSAL TASK (VDR)
Age-related impairments in the R6/2 Huntington's disease mouse model
Morton, Skillings, Bussey & Saksida (2006) Nature Methods
PAIRED ASSOCIATE LEARNING TASK (PAL)
Intra-hippocampal infusions of MK-801 impair performance of the PAL task
But perhaps the most promising data from this task comes from our studies using donepezil, an acetylcholinesterase inhibitor that is a commonly prescribed drug for AD in the UK. Donepezil enhanced performance on PAL in a dose-dependent manner. This result shows that PAL is able to detect cognitive enhancements, as well as impairments.
LOCATION DISCRIMINATION TASK (LD)
McTighe, Mar, Romberg, Bussey & Saksida (2009) NeuroReport
Neurogenesis knock-down impairs pattern separation in the Location Discrimination Task
Clelland, Choi, Romberg, Clemenson, Fragniere, Tyers, Jessberger, Saksida, Barker, Gage & Bussey (2009) Science
Dorsal hippocampal lesions impair pattern separation in the Location Discrimination Task
McTighe, Mar, Romberg, Bussey & Saksida (2009) NeuroReport
AUTOSHAPING
Data from C57/Bl6 mice on the Autoshaping task. A stimulus (white rectangle) is shown on either the left or right of the screen for (usually) 10 seconds. Over trials the animal learns that the CS+ predicts reward and makes increasingly more responses to the CS+, and fewer responses to the CS-.
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