产品介绍
英文名称 Anti-TBX2/T-box2
中文名称 新型抑癌基因抗体
新型抑癌基因抗体别 名 T-box Protein 2; T-box transcription factor TBX2; T-box protein 2; FLJ10169; HGNC: 11597; T box 2; T box transcription factor TBX2; TBX2; TBX2_HUMAN.
浓 度 1mg/1ml
规 格 0.2ml/200μg
抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human, Mouse, Rat
产品类型 一抗
研究领域 肿瘤 细胞生物 信号转导 细胞凋亡
蛋白分子量 predicted molecular weight: 74kDa
新型抑癌基因抗体性 状 Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from human TBX2
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product is the human homolog of mouse Tbx2, and shares strong sequence similarity with Drosophila omb protein. Expression studies indicate that this gene may have a potential role in tumorigenesis as an immortalizing agent. Transcript heterogeneity due to alternative polyadenylation has been noted for this gene.
Function : Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation. Acts as a negative regulator of PML function in cellular senescence.
Subunit : Interacts with PML (isoform-PML-2, isoform PML-3 and isoform PML-4).
Subcellular Location : Nucleus.
Tissue Specificity : Expressed primarily in adult in kidney, lung, and placenta. Weak expression in heart and ovary.
Similarity : Contains 1 T-box DNA-binding domain.
新型抑癌基因抗体Database links : UniProtKB/Swiss-Prot: Q13207.3
经研究发现，在人黑色素瘤及很多恶性肿瘤组织中普遍存在TBX2基因表达的增高,该蛋白与恶性肿瘤的发生、发展密切相关.TBX2基因被认为是一种新发现的抑癌基因。
来宝会员