产品介绍
英文名称 Anti-TRAF7
中文名称 肿瘤坏死因子受体相关因子7抗体
肿瘤坏死因子受体相关因子7抗体别 名 E3 ubiquitin protein ligase TRAF7; RFWD1; Ring finger and WD repeat domain 1; RING finger protein 119; RNF119; TNF receptor associated factor 7; TRAF7_HUMAN.
浓 度 1mg/1ml
规 格 0.1ml/100μg 0.2ml/200μg
抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep
产品类型 一抗
研究领域 细胞生物 免疫学 信号转导 细胞凋亡
蛋白分子量 predicted molecular weight: 75kDa
肿瘤坏死因子受体相关因子7抗体性 状 Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from human TRAF7
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 TNF receptor associated factor 7 (TRAF7) is an E3 ubiquitin ligase capable of auto ubiquination, following phosphorylation by MAP3K3. TRAF7 potentiates MEKK3 mediated activation of the NFkappaB, JUN/AP1 and DDIT3 transcriptional regulators. TRAF7 induces apoptosis when over expressed.
Function : E3 ubiquitin ligase capable of auto-ubiquitination, following phosphorylation by MAP3K3. Potentiates MEKK3-mediated activation of the NF-kappa-B, JUN/AP1 and DDIT3 transcriptional regulators. Induces apoptosis when overexpressed.
Subunit : Homodimer. Interacts with MAP3K3 and promotes the kinase activity of this enzyme.
Subcellular Location : Colocalizes with MAP3K3 to vesicle like structures throughout the cytoplasm.
Tissue Specificity : Ubiquitously expressed with high levels in skeletal muscle, heart, colon, spleen, kidney, liver and placenta.
Post-translational modifications : Phosphorylated by MAP3K3.
Ubiquitinates itself upon phosphorylation.
肿瘤坏死因子受体相关因子7抗体Similarity : Belongs to the WD repeat TRAF7 family.
Contains 1 RING-type zinc finger.
Contains 1 TRAF-type zinc finger.
Contains 7 WD repeats.
Database links : UniProtKB/Swiss-Prot: Q6Q0C0.1
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