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产品介绍

胃癌肿瘤分子标志物检测试剂盒

Stomach Neoplasms Molecular Marker (AURKB, MAPK8 and MARK1) Detection Kit

 

Description: The kit provides a means of performing Stomach Neoplasms detection method based on kinase activity assays. Three targets of molecular marker (AURKB, MAPK8 and MARK1) are involved in Stomach Neoplasms. This kit includes Streptavidin Coated Plates and specific Substrate-Peptides (biotinylated peptide substrates) for detection of the activity of AURKB, MAPK8 (JNK) and MARK1 which indicate the prognosis of Stomach Neoplasms.

Molecular Markers in Stomach Neoplasms

 

Disease	Molecular Marker	Gene ID	Gene Disease Relation
Stomach Neoplasms	AURKB	9212	marker/mechanism
Stomach Neoplasms	MAPK8	5599	marker/mechanism
Stomach Neoplasms	MARK1	4139	marker/mechanism

 

- Molecular markers for drug discovery and life science research (mechanism).

Peptide Core Sequence: 

Specific Substrate-Peptides for Stomach Neoplasms Molecular Marker

 

Molecular Marker	Substrate-Peptide	Residue	Reaction Type
AURKB	Peptides Mix	Ser-387	Phosphorylation
MAPK8	Peptides Mix	Ser-104	Phosphorylation
MARK1	Peptides Mix	Ser-928	Phosphorylation

 

Label of Substrate-Peptides:  Biotinylated

Quality Control: The substrate peptide was selected using our Stomach Neoplasms Detection Kit. The quality of the biotinylated peptide was evaluated by reverse-phase HPLC and by mass spectrometry.

Storage: 

Store at 4 °C, Avoid Freeze.

Background:

Aurora B kinase (AURKB) is a protein that functions in the attachment of the mitotic spindle to the centromere.. Abnormally elevated levels of Aurora B kinase cause unequal chromosomal separation during cell division, resulting in the formation of cells with abnormal numbers of chromosomes, which are both a cause and driver of cancer.Inhibition of Aurora B kinase by BI811283 in cancer cells leads to the formation of cells with severely abnormal numbers of chromosomes (polyploid). Counterintuitively, inhibition of Aurora B kinase actually causes the polyploid cells formed to continue dividing however, because these cells have severe chromosomal abnormalities, they eventually stop dividing or undergo cell death. Mitogen-activated protein kinase 8 (MAPK8) is an enzyme that in humans is encoded by the MAPK8 gene. The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha-induced apoptosis. This kinase is also involved in UV radiation-induced apoptosis, which is thought to be related to the cytochrome c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternately spliced transcript variants encoding distinct isoforms have been reported. Serine/threonine-protein kinase (MARK1) is an enzyme that in humans is encoded by the MARK1 gene.

 

联系方式：

拜珐公司： 业务手机：18221844720   电话：021-34315602  邮箱：biopharmsoft@sina.com