产品介绍
膀胱癌肿瘤分子标志物检测试剂盒
货号: BR-1027U 规格: 96 Assay 价格: ￥3926.00
Urinary Bladder Neoplasms Molecular Marker (EGFR, FGFR3, SRC) Detection Kit
Description: The kit provides a means of performing Urinary Bladder Neoplasms detection method based on kinase activity assay. Three targets of molecular marker (EGFR, FGFR3 and SRC) are involved in Urinary Bladder Neoplasms. This kit includes Streptavidin Coated Plates and specific SubstratePeptides (biotinylated peptide substrates) for detection of the activity of EGFR, FGFR3 and SRC which indicate the prognosis of Urinary Bladder Neoplasms.
Molecular Markers in Urinary Bladder Neoplasms
|
Disease
|
Molecular Marker
|
Gene ID
|
Gene Disease Relation
|
|
Urinary Bladder Neoplasms
|
EGFR
|
1956
|
marker/mechanism
|
|
Urinary Bladder Neoplasms
|
FGFR3
|
2261
|
marker/mechanism
|
|
Urinary Bladder Neoplasms
|
SRC
|
6714
|
marker/mechanism
|
- Molecular markers for drug discovery and life science research (mechanism).
Peptide Core Sequence:
Specific Substrate-Peptides for Urinary Bladder Neoplasms Molecular Marker
|
Molecular Marker
|
Substrate-Peptide
|
Residue
|
Reaction_Type
|
|
EGFR
|
Peptides Mix
|
Tyr-743
|
Phosphorylation
|
|
FGFR3
|
Peptides Mix
|
Tyr-760
|
Phosphorylation
|
|
SRC
|
Peptides Mix
|
Tyr-200
|
Phosphorylation
|
Label of Substrate-Peptides: Biotinylated.
Quality Control: The substrate peptide was selected using our Urinary Bladder Neoplasms Diagnosis Kit. The quality of the biotinylated peptide was evaluated by reverse-phase HPLC and by mass spectrometry.
Storage:
Store at 4 °C, Avoid Freeze.
Background:
EGFR (epidermal growth factor receptor) exists on the cell surface and is activated by binding of its specific ligands, including epidermal growth factor and transforming growth factor α (TGFα) (note, a full list of the ligands able to activate EGFR and other members of the ErbB family is given in the ErbB article). ErbB2 has no known direct activating ligand, and may be in an activated state constitutively or become active upon heterodimerization with other family members such as EGFR. Upon activation by its growth factor ligands, EGFR undergoes a transition from an inactive monomeric form to an active homodimer – although there is some evidence that preformed inactive dimers may also exist before ligand binding. FGFR3 is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. Src (pronounced "sarc" as it is short for sarcoma) is a proto-oncogene encoding a tyrosine kinase originally discovered by J. Michael Bishop and Harold E. Varmus, for which they won the 1989 Nobel Prize in Physiology or Medicine. It belongs to a family of non-receptor tyrosine kinases called Src family kinases. The discovery of Src family proteins has been instrumental to the modern understanding of cancer as a disease where normally healthy cellular signalling has gone awry.
联系方式：
拜珐公司： 业务手机：18221844720 电话：021-34315602 邮箱：biopharmsoft@sina.com
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