产品介绍
Ionomycin常用于转运钙离子穿过各种生物膜。加入Ionomycin最常用于提高细胞内的钙离子水平。通过提高细胞内钙离子水平,Ionomycin可以诱导神经细胞发生细胞凋亡,可以诱导一些细胞产生cell cycle arrest,也可以产生多种由于细胞内钙离子水平升高而产生的其它生物功能。
Ionomycin分子量为747.07,分子式为C41H70CaO9,CAS Number:56092-82-1
Sizes: |
10 x 100 mg |
1 mg |
5 x 1 mg |
5 mg |
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Bioassay: |
Ionomycin induced cytosolic Ca2+ increase.
Ca2+ traces from Fluo-3 AM loaded C6 glioma cells treated with 1mM Ionomycin. |
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Liu, W.C. et al. (1978) J. Antibiot. (Tokyo) 31, 815. |
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Kauffman, R.F. (1980) J. Biol. Chem. 255, 2735. |
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Morgan, A.J. and Jacob, R. (1994) Biochem. J. 300, 665. |
5.
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Chatila, T. et al. (1989) The J. of Immunology 143, 41283. |
6.
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Takei, N. et al. (1994) Brain Res. 652, 65. |
7.
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Aagaard-Tillery, K.M. et al. (1995) J. Immunol. 155, 3297.
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Ionomycin, is a narrow spectrum antibiotic for Gram-positive bacteria, produced by Streptomyces conglobatus. In mammals cells ionomycin acts as a potent and selective Ca2+ionophore, more effective than A23187. The enhancement of Ca2+ influx by Ionomycin, caused by direct stimulation of store-regulated cation entry and not by a direct action at the plasma membrane.1-4 Ionomycin induces hydrolysis of phosphoinositides, activation of PKC in human T cells and apoptosis in various cells lines.5-7