USPIO 一种新型的磁性纳米生物材料-瑞禧生物

来宝网 2016/3/12点击1593次

Fe₃O₄磁性纳米颗粒由于同时具备磁性颗粒和纳米颗粒的双重优势，已经广泛应用于靶向药物载体，细胞分离，核磁共振，免疫分析，核酸杂交等生物医学领域。同时，这种超顺磁性材料在催化领域也具有很好的应用前景，可以作为液相小尺寸催化剂的催化载体，改善催化剂分离难的状况，但是 Fe₃O₄磁性纳米粒子易氧化，比表面积较高，具有强烈的聚集倾向，难以直接应用．采用无定型SiO₂对Fe₃O₄磁性纳米粒子进行表面包覆，SiO₂包覆层增加了其化学稳定性，同时 SiO₂的无毒性和表面羟基的存在提高了其生物相容性，拓宽了Fe₃O₄磁性纳米粒子在生物，催化等领域的应用。

１．Fe₃O₄磁性纳米颗粒的制备：常温下将2.16gFeCl₃·6H₂O溶解于１００ｍｌ去离子水中，在氮气保护下加入Na₂SO₃溶液，磁力搅拌１５ｍｉｎ，快速加入５ｍｌ质量分数为２５％－２８％的浓氨水，溶液迅速变黑，在６０℃油浴中反应３０ｍｉｎ，然后逐滴加入0.3g的柠檬酸，调节温度值８０℃，反应１ｈ，之后冷却至室温，沉降磁球，用丙酮和去离子水清洗磁球数次，最后在去离子水中超声分散，得到的就是稳定的Fe₃O₄磁性纳米颗粒。

２．油相Fe₃O₄磁性纳米颗粒的制备：在磁性材料合成中，油酸是以后总常用的纳米颗粒稳定剂。采用热解油酸铁复合物制备Fe₃O₄磁性纳米颗粒，并通过透射电子显微镜（ＴＥＭ），Ｘ－射线粉末衍射仪（Ｘ－ＲＤ）和振动样品磁强计（ＶＳＭ）对其进行表征。得到的Fe3O4磁性纳米颗粒呈球形，在室温下具有超顺磁，并且由于油酸的稳定作用，纳米颗粒在正己烷等非极性溶剂中具有良好的分散性。

３．Fe₃O₄@SiO₂纳米粒子制备：以O P-10，正丁醇，环己烷和浓氨水分别作为表面活性剂，助表面活性剂，油相和水相，按一定的比例混合配成微乳液体，剧烈搅拌，再依次加入酸洗处理过的Fe₃O₄胶体溶液和ＴＥＯＳ，反应完成后使用体积比为 75 ％的丙酮水溶液破乳，静置分层后，去除上清液，对下层沉淀物用乙醇清洗数次，最后得到Fe₃O₄@SiO₂磁性纳米复合粒子。

Fe₃O₄磁性纳米颗粒的应用：

１.生物医药磁性高分子微球（也称免疫磁性微球）是一种由磁性纳米颗粒和高分子骨架材料制备而成的生物医用材料

２．磁性液体，是一种新型功能材料，它将是众多的纳米级的铁磁性或亚铁磁性微粒高度弥散于液态载液中而构成的一种高稳定的胶体溶液，微粒与载液通过表面活性剂混成的这种磁性液体即使在重力场、电场、磁场作用下也能长期稳定的存在，不产生沉淀与分离。

３Fe₃O₄颗粒在很多工业反应中被用作催化剂 , 如制取NH₃ (Haber 制氨法) 、高温水气转移反应和天然气的去硫反应等。

４.微波吸波材料

５.磁性纳米材料被广泛用作各种抗癌药物的载体，形成一种磁靶向给药系统；用磁性纳米材料制成的磁性微球还可广泛用于磁性免疫细胞的分离，核磁共振造影成像等方面。

西安瑞禧生物科技有限公司的磁性纳米颗粒种类划分

瑞禧生物-Magnetic Nanoparticles磁性纳米颗粒分类：

Magnetic Nanoparticles普通磁性纳米颗粒

Superparamagnetic Iron Oxide nanoparticles超顺磁性氧化铁纳米粒子

oleic acid coating Fe3O4 Magnetic Nanoparticles油酸包裹的磁性纳米颗粒

SiO2 coated Fe3O4 Magnetic Nanoparticles二氧化硅包裹的磁性纳米粒子产品

BSA coated Fe3O4 Magnetic Nanoparticles 牛血清白蛋白包裹的磁性纳米颗粒

PLL coated Fe3O4 Magnetic nanoparticles多聚赖氨酸包裹的四氧化三铁磁性纳米颗粒

PEI coated Fe3O4 Magnetic nanoparticles聚乙烯亚胺包裹的四氧化三铁磁性纳米颗粒

PLGA/PCL/PLA coating Fe3O4 Magnetic Nanoparticles 生物降解材料包裹磁性纳米颗粒

Adriamycin coating Fe3O4 Magnetic Nanoparticles 阿霉素包裹磁性纳米颗粒

magnetic mesoporous silica nanoparticles（M-MSNs）介孔二氧化硅磁性纳米颗粒（可修饰荧光分子和NH2/COOH功能基团）

PEG Fe3O4 Magnetic nanoparticles （PEG末端连NH2,N3,MAL, Biotin，COOH等等）

Anti-Fe3O4 Magnetic nanoparticles 抗体交联磁性纳米颗粒

表面基团功能化Superparamagnetic Iron Oxide nanoparticles超顺磁性氧化铁纳米粒子（基团有NH2,COOH,OH,MAL,Biotin等等）

Fluorescent labeled Magnetic Nanoparticles荧光标记磁性纳米颗粒（FITC,RB,CY3,CY5）

Bioconjugated Magnetic Nanoparticles生物蛋白磁性纳米颗粒（Concanavilin A Transferrin

Protein A，Protein G，Folic Acid，RGD，半乳糖，葡聚糖、Streptavidin、Lysozyme、Hylauronic acid、Insulin、Chitosan）

四氧化三铁磁性纳米微球Fe3O4 Magnetic Microspheres

功能化四氧化三铁磁性纳米微球Fe3O4 Magnetic Microspheres

Magnetic Nanoparticles磁性纳米颗粒系列产品总目录：

Magnetic Nanoparticles普通磁性纳米颗粒列表：

5 nm Fe3O4 nanoparticles with oleic acid coating in Ethanol/water 5mg/ml 1ml 5ml 10ml

10 nm Fe3O4 nanoparticles with oleic acid coating in Ethanol/water 5mg/ml 1ml 5ml 10ml

15 nm Fe3O4 nanoparticles with oleic acid coating in Ethanol/water 5mg/ml 1ml 5ml 10ml

20 nm Fe3O4 nanoparticles with oleic acid coating in Ethanol/water 5mg/ml 1ml 5ml 10ml

25 nm Fe3O4 nanoparticles with oleic acid coating in Ethanol/water 5mg/ml 1ml 5ml 10ml

30 nm Fe3O4 nanoparticles with oleic acid coating in Ethanol/water 5mg/ml 1ml 5ml 10ml

35 nm Fe3O4 nanoparticles with oleic acid coating in Ethanol/water 5mg/ml 1ml 5ml 10ml

40 nm Fe3O4 nanoparticles with oleic acid coating in Ethanol/water 5mg/ml 1ml 5ml 10ml

50 nm Fe3O4 nanoparticles with oleic acid coating in Ethanol/water 5mg/ml 1ml 5ml 10ml

60 nm Fe3O4 nanoparticles with oleic acid coating in Ethanol/water 5mg/ml 1ml 5ml 10ml

70 nm Fe3O4 nanoparticles with oleic acid coating in Ethanol/water 5mg/ml 1ml 5ml 10ml

80 nm Fe3O4 nanoparticles with oleic acid coating in Ethanol/water 5mg/ml 1ml 5ml 10ml

90 nm Fe3O4 nanoparticles with oleic acid coating in Ethanol/water 5mg/ml 1ml 5ml 10ml

100 nm Fe3O4 nanoparticles with oleic acid coating in Ethanol/water 5mg/ml 1ml 5ml 10ml

SiO2 Magnetic Nanoparticles二氧化硅包裹的磁性纳米粒子产品列表：

5 nm Fe3O4 nanoparticles with SiO2 coating in Ethanol/water 5mg/ml 1ml 5ml 10ml

10 nm Fe3O4 nanoparticles with SiO2 coating in Ethanol/water 5mg/ml 1ml 5ml 10ml

15 nm Fe3O4 nanoparticles with SiO2 coating in Ethanol/water 5mg/ml 1ml 5ml 10ml

20 nm Fe3O4 nanoparticles with SiO2 coating in Ethanol/water 5mg/ml 1ml 5ml 10ml

25 nm Fe3O4 nanoparticles with SiO2 coating in Ethanol/water 5mg/ml 1ml 5ml 10ml

30 nm Fe3O4 nanoparticles with SiO2 coating in Ethanol/water 5mg/ml 1ml 5ml 10ml

35 nm Fe3O4 nanoparticles with SiO2coating in Ethanol/water 5mg/ml 1ml 5ml 10ml

40 nm Fe3O4 nanoparticles with SiO2 coating in Ethanol/water 5mg/ml 1ml 5ml 10ml

50 nm Fe3O4 nanoparticles with SiO2 coating in Ethanol/water 5mg/ml 1ml 5ml 10ml

60 nm Fe3O4 nanoparticles with SiO2 coating in Ethanol/water 5mg/ml 1ml 5ml 10ml

70 nm Fe3O4 nanoparticles with SiO2 coating in Ethanol/water 5mg/ml 1ml 5ml 10ml

80 nm Fe3O4 nanoparticles with SiO2 coating in Ethanol/water 5mg/ml 1ml 5ml 10ml

90 nm Fe3O4 nanoparticles with SiO2 coating in Ethanol/water 5mg/ml 1ml 5ml 10ml

100 nm Fe3O4 nanoparticles with SiO2 coating in Ethanol/water 5mg/ml 1ml 5ml 10ml

Superparamagnetic Iron Oxide nanoparticles超顺磁性氧化铁纳米粒子列表：

5 nm Fe3O4 nanoparticles with oleic acid coating in chloroform,10 mg, 1 mL (10 mg/mL, Fe)

10 nm Fe3O4 nanoparticles with oleic acid coating in chloroform,10 mg, 1 mL (10 mg/mL, Fe)

20 nm Fe3O4 nanoparticles with oleic acid coating in chloroform,10 mg, 1 mL (10 mg/mL, Fe)

5 nm Fe3O4 nanoparticles with Oligo-PEG-Dopa oligomer coating, in water 1ml 5 mg/mL

10 nm Fe3O4 nanoparticles with Oligo-PEG-Dopa oligomer coating, in water 1ml 5 mg/mL

20 nm Fe3O4 nanoparticles with Oligo-PEG-Dopa oligomer coating, in water 1ml 5 mg/mL

PEG功能化交联Superparamagnetic Iron Oxide nanoparticles产品列表：

5 nm Fe3O4 nanoparticles-Catechol-PEG400-COOH in water 2 mL (5 mg/mL, Fe)

10 nm Fe3O4 nanoparticles-Catechol-PEG400-COOH in water 2 mL (5 mg/mL, Fe)

20 nm Fe3O4 nanoparticles-Catechol-PEG400-COOH in water 2 mL (5 mg/mL, Fe)

5 nm Fe3O4 nanoparticles-Catechol-PEG400-NH2 in water 2 mL (5 mg/mL, Fe)

10 nm Fe3O4 nanoparticles-Catechol-PEG400-NH2 in water 2 mL (5 mg/mL, Fe)

20 nm Fe3O4 nanoparticles-Catechol-PEG400-NH2 in water 2 mL (5 mg/mL, Fe)

5 nm Fe3O4 nanoparticles-Catechol-PEG400-N3 in water 2 mL (5 mg/mL, Fe)

10 nm Fe3O4 nanoparticles-Catechol-PEG400-N3 in water 2 mL (5 mg/mL, Fe)

20 nm Fe3O4 nanoparticles-Catechol-PEG400-N3 in water 2 mL (5 mg/mL, Fe)

5 nm Fe3O4 nanoparticles-Catechol-PEG400-Biotin in water 2 mL (5 mg/mL, Fe)

10 nm Fe3O4 nanoparticles-Catechol-PEG400-Biotin in water 2 mL (5 mg/mL, Fe)

20 nm Fe3O4 nanoparticles-Catechol-PEG400-Biotin in water 2 mL (5 mg/mL, Fe)

功能化Superparamagnetic Iron Oxide nanoparticles超顺磁性氧化铁纳米粒子列表：

10 nm Fe2O3 nanoparticles-polylysine (magnetite,Fe2O3) Surface: polylysine 2.5ml 1mg/ml

10 nm Fe3O4 nanoparticles-PEI (magnetite,Fe3O4) Surface: PEI 2.5ml 1mg/ml

10 nm Fe3O4 nanoparticles-oleic acid (magnetite,Fe3O4) Surface:oleic acid 2.5ml 1mg/ml

10 nm Fe3O4 nanoparticles-COOH 2.5ml 4mg/ml

10 nm Fe2O3 nanoparticles-COOH 2.5ml 4mg/ml

10 nm Fe3O4 nanoparticles-NH2 2.5ml 4mg/ml

10 nm Fe2O3 nanoparticles-NH2 2.5ml 4mg/ml

功能化磁性纳米颗粒Magnetic Nanoparticles产品列表：

Magnetic Nanoparticles, Amine Functional 25~30 nm 1 mL

Magnetic Nanoparticles, Amine Functional 100~200 nm 1 mL

Magnetic Nanoparticles, Amine Functional 350~400 nm 1 mL

Magnetic Nanoparticles, Carboxyl Functional 25~30 nm 1 mL

Magnetic Nanoparticles, Carboxyl Functional 100~200 nm 1 mL

Magnetic Nanoparticles, Carboxyl Functional 350~400 nm 1 mL

Magnetic Nanoparticles, Biotin Functional 25~30 nm 1 mL

Magnetic Nanoparticles, Biotin Functional 100~200 nm 1 mL

Magnetic Nanoparticles, Biotin Functional 350~400 nm 1 mL

Magnetic Nanoparticles, Hydroxyl Functional 25~30 nm 1 mL

Magnetic Nanoparticles, Hydroxyl Functional 100~200 nm 1 mL

Magnetic Nanoparticles, Hydroxyl Functional 350~400 nm 1 mL

Fluorescent labeled Magnetic Nanoparticles荧光标记磁性纳米颗粒产品列表：

Magnetic Nanoparticles, FITC (Fluorescein) Labeled 20~30 nm 0.5 mL

Magnetic Nanoparticles, Rhodamine B Labeled 20~30 nm 0.5 mL

Magnetic Nanoparticles, Cy3 Labeled 20~30 nm 0.5 mL

Magnetic Nanoparticles, Cy5 Labeled 20~30 nm 0.5 mL

Magnetic Nanoparticles, Cy5.5 Labeled 20~30 nm 0.5 mL

Bioconjugated Magnetic Nanoparticles生物蛋白磁性纳米颗粒产品列表：

Fe3O4 Magnetic Nanoparticles, Concanavilin A Labeled 25~30 nm 0.5 mL

Fe3O4 Magnetic Nanoparticles, Transferrin Labeled 25~30 nm 0.5 mL

Fe3O4 Magnetic Nanoparticles, Protein A Labeled 25~30 nm 0.5 mL

Fe3O4 Magnetic Nanoparticles, Protein G Labeled 25~30 nm 0.5 mL

Fe3O4 Magnetic Nanoparticles, RGD Labeled 25~30 nm 0.5 mL

Fe3O4 Magnetic Nanoparticles, 半乳糖Labeled 25~30 nm 0.5 mL

Fe3O4 Magnetic Nanoparticles, 葡聚糖Labeled 25~30 nm 0.5 mL

Fe3O4 Magnetic Nanoparticles, Streptavidin Labeled 25~30 nm 0.5 mL

Fe3O4 Magnetic Nanoparticles, Lysozyme Labeled 25~30 nm 0.5 mL

Fe3O4 Magnetic Nanoparticles, Hylauronic acid Labeled 25~30 nm 0.5 mL

Fe3O4 Magnetic Nanoparticles, Insulin Labeled 25~30 nm 0.5 mL

Fe3O4 Magnetic Nanoparticles, Chitosan Labeled 25~30 nm 0.5 mL

Fe3O4 Magnetic Nanoparticles, BSA Labeled 25~30 nm 0.5 mL

Fe3O4 Magnetic Nanoparticles, PLL Labeled 25~30 nm 0.5 mL

Fe3O4 Magnetic Nanoparticles, PEI Labeled 25~30 nm 0.5 mL

Fe3O4 Magnetic Nanoparticles, Adriamycin Labeled 25~30 nm 0.5 mL

Fe3O4 Magnetic Nanoparticles, Anti Labeled 25~30 nm 0.5 ml

magnetic mesoporous silica nanoparticles（M-MSNs）介孔二氧化硅磁性纳米颗粒产列表：

mesoporous silica coated Fe3O4 Magnetic Nanoparticles 30nm 5mg/ml 1ml

mesoporous silica coated Fe3O4 Magnetic Nanoparticles 40nm 5mg/ml 1ml

mesoporous silica coated Fe3O4 Magnetic Nanoparticles 50nm 5mg/ml 1ml

mesoporous silica coated Fe3O4 Magnetic Nanoparticles 60nm 5mg/ml 1ml

mesoporous silica coated Fe3O4 Magnetic Nanoparticles Amine Functional 30nm 5mg/ml 1ml

mesoporous silica coated Fe3O4 Magnetic Nanoparticles Amine Functional 40nm 5mg/ml 1ml

mesoporous silica coated Fe3O4 Magnetic Nanoparticles Amine Functional 50nm 5mg/ml 1ml

mesoporous silica coated Fe3O4 Magnetic Nanoparticles Amine Functional 60nm 5mg/ml 1ml

mesoporous silica coated Fe3O4 Magnetic Nanoparticles COOH Functional 30nm 5mg/ml 1ml

mesoporous silica coated Fe3O4 Magnetic Nanoparticles COOH Functional 40nm 5mg/ml 1ml

mesoporous silica coated Fe3O4 Magnetic Nanoparticles COOH Functional 50nm 5mg/ml 1ml

mesoporous silica coated Fe3O4 Magnetic Nanoparticles COOH Functional 60nm 5mg/ml 1ml

mesoporous silica coated Fe3O4 Magnetic Nanoparticles FITC Labeled 30nm 5mg/ml 1ml

mesoporous silica coated Fe3O4 Magnetic Nanoparticles FITC Labeled 40nm 5mg/ml 1ml

mesoporous silica coated Fe3O4 Magnetic Nanoparticles FITC Labeled 50nm 5mg/ml 1ml

mesoporous silica coated Fe3O4 Magnetic Nanoparticles FITC Labeled 60nm 5mg/ml 1ml

四氧化三铁磁性纳米微球Fe3O4 Magnetic Microspheres产品列表：

R-N-0089 Fe3O4 Magnetic Microspheres 100-200 nm 表面基团:-NH2

R-N-0090 Fe3O4 Magnetic Microspheres 200-300 nm 表面基团:-NH2

R-N-0091 Fe3O4 Magnetic Microspheres 300-400 nm 表面基团:-NH2

R-N-0092 Fe3O4 Magnetic Microspheres 400-500 nm 表面基团:-NH2

R-N-0093 Fe3O4 Magnetic Microspheres 500-600 nm 表面基团:-NH2

R-N-0094 Fe3O4 Magnetic Microspheres 100-200 nm 表面基团:-COOH

R-N-0095 Fe3O4 Magnetic Microspheres 200-300 nm 表面基团:-COOH

R-N-0096 Fe3O4 Magnetic Microspheres 300-400 nm 表面基团:-COOH

R-N-0097 Fe3O4 Magnetic Microspheres 400-500 nm 表面基团:-COOH

R-N-0098 Fe3O4 Magnetic Microspheres 500-600 nm 表面基团:-COOH

R-N-0099 Fe3O4 Magnetic Microspheres 100-200 nm 表面基团:- Epoxy

R-N-0100 Fe3O4 Magnetic Microspheres 200-300 nm 表面基团:- Epoxy

R-N-0101 Fe3O4 Magnetic Microspheres 300-400 nm 表面基团:- Epoxy

R-N-0102 Fe3O4 Magnetic Microspheres 400-500 nm 表面基团:- Epoxy

R-N-0103 Fe3O4 Magnetic Microspheres 500-600 nm 表面基团:- Epoxy

R-N-0104 Fe3O4 Magnetic Microspheres 100-200 nm 表面基团:- SiOH

R-N-0105 Fe3O4 Magnetic Microspheres 200-300 nm 表面基团:- SiOH

R-N-0106 Fe3O4 Magnetic Microspheres 300-400 nm 表面基团:- SiOH

R-N-0107 Fe3O4 Magnetic Microspheres 400-500 nm 表面基团:- SiOH

R-N-0108 Fe3O4 Magnetic Microspheres 500-600 nm 表面基团:- SiOH

功能化四氧化三铁磁性纳米微球Fe3O4 Magnetic Microspheres产品列表：

Fe3O4 Magnetic Microspheres Composition: Fe3O4 Surface: COOH 2.5um 5ml

Fluorescent Fe3O4 Magnetic Microspheres-COOH 435-455nm 2.5um 1ml

Fluorescent Fe3O4 Magnetic Microspheres-COOH 510-525nm 2.5um 1ml

Fluorescent Fe3O4 Magnetic Microspheres-COOH 560-575nm 2.5um 1ml

Fluorescent Fe3O4 Magnetic Microspheres-COOH 615-630nm 2.5um 1ml

Fluorescent Fe3O4 Magnetic Microspheres-COOH 650-665nm 2.5um 1ml

西安瑞禧生物科技有限公司可以提供系列纳米试剂产品：

1.纳米金粒子产品Gold nanoparticles及其功能化衍生试剂-常规浓度0.1mg/ml

? Gold Nanoparticles, 0.01% Au普通的纳米金粒径从2-200nm不等

? 功能化基团的纳米金，基团包括NH2，MAL，COOH，Biotin，NHS等

? 亲和素和链酶亲和素包裹的纳米金Gold Nanoparticles Streptavidin/Neutravidin

? 蛋白包裹纳米金产品包裹的蛋白包括有Protein A、Galactose、Transferrin、BAS、Dextran

? 抗体连接的纳米金产品有羊抗人IgG/羊抗鼠IgG/IgA/IgM等

? 荧光素标记的纳米金荧光素包括有FITC RB CY3 CY5 纳米金粒径15-50nm

? 短链PEG耦合的纳米金衍生物，PEG分子量400和500，末端基团NH2 COOH N3 BIO

? 长链PEG耦合的纳米金衍生物，PEG分子量5000，末端基团NH2 COOH Biotin

? 介孔二氧化硅包裹纳米金粒子

2. Silver Nanoparticles银纳米产品及其衍生试剂：

? Spherical Silver Nanoparticle普通球形银纳米粒子粒径从10-100nm不等

? Anti Silver Nanoparticle Conjugates抗体银纳米粒子交联

? Protein A Silver Nanoparticle Conjugates 蛋白银纳米粒子交联产品

? PEG Silver Nanoparticle Conjugates聚乙二醇银纳米粒子交联产品

3.磁性纳米颗粒及其相关产品，超顺磁性纳米颗粒

? 油酸包裹四氧化三铁磁性纳米颗粒溶在有机溶剂中-脂溶性的产品

? 水溶性的磁性纳米颗粒无包裹分散在水中

? 二氧化硅包裹的磁性纳米颗粒

? BSA coated Fe3O4 Magnetic Nanoparticles

? PLL coated Fe3O4 nanoparticles

? PEI coated Fe3O4 nanoparticles

? PLGA/PCL/PLA coating Fe3O4 Magnetic Nanoparticles 生物降解材料包裹磁性纳米颗粒

? 介孔二氧化硅磁性纳米颗粒

? PEG和磁性纳米颗粒交联的产品

? 功能化磁性纳米颗粒Magnetic Nanoparticles

? Fluorescent labeled Magnetic Nanoparticles荧光标记磁性纳米颗粒

? Bioconjugated Magnetic Nanoparticles生物蛋白磁性纳米颗粒

? Anti-Magnetic Nanoparticles 磁性纳米颗粒连抗体

? 氧化三铁磁性纳米微球Fe3O4 Magnetic Microspheres

4. Polystyrene Beads聚苯乙烯微球

? Polystyrene Beads常规聚苯乙烯微球

? 功能化聚苯乙烯微球Fucntional Polystyrene Beads

? Fluorescent Polystyrene Beads荧光聚苯乙烯微球

? PLGA Beads聚乳酸-羟基乙酸共聚物微球

? PMMA Beads聚甲基丙烯酸甲酯(PMMA)微球

? Gold Nanorods金纳米棒及其功能化产品

? Functional Agarose Beads功能性琼脂糖珠产品

? Multiwalled Carbon Nanotubes纳米管及功能性纳米管产品

? Fluorescent Quantum Dots荧光量子点产品

西安瑞禧生物科技有限公司

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超微超顺磁性氧化铁纳米粒的制备及性能研究

[摘要]目的：制备超微超顺磁性氧化铁纳米粒，并研究其物理、磁学性质及传递特性，探讨其作为磁共振阴性对比剂的可能性。方法：共沉淀一步法制备葡聚糖包被的四氧化三铁纳米粒，采用X射线粉末衍射法(XRD)分析其内部晶体结构，傅立叶红外光谱仪(FT-IR)分析其表面结构，透射电镜(TEM)及动态激光粒度仪测量其大小，振动样品磁强计(VSM)检测磁化率等参数。此外，采用原子吸收光谱仪检测家兔血和不同脏器中的样品铁含量，MRI观察注射样品后肝、淋巴结的增强效果。结果：所得样品核心为四氧化三铁晶体，表面包覆葡聚糖，核心粒径6～8nm，整体颗粒直径为33nm，样品铁含量为0.2mmol/L。磁化曲线表现为超顺磁性，饱和磁化强度为48.1emu/g。样品在家兔体内血循环时间较长(>6h),主要分布至脾、肝、肺、心、淋巴等网状内皮系统，注射样品后肝、淋巴结在T2WI信号明显降低。结论：实验表明，制备的样品可作为一种新型的磁共振阴性造影剂，广泛用于肝脾、淋巴结等多种疾病的诊断和治疗。

超微超顺磁性氧化铁纳米粒；物理性质；磁学性质；传递特性；磁共振阴性对比剂

[中图分类号]R394[文献标识码]A[文章编号]1673-7210（2010）07（a）-033－05

Preparationandperformancestudyonultrasmallsuperparamagneticironoxide(USPIO)nanoparticles

LIUGuohua1,CHENYanming1,CAIQing2,CHENXiaojun1,HONGRuoyu3

(1.DepartmentofRespiration,East-sectionoftheAffliatedSuzhouMunicipalHospitalofNanjingMedicalUniversity,Suzhou215001,China;2.DepartmentofRadiology,East-sectionoftheAffliatedSuzhouMunicipalHospitalofNanjingMedicalUniversity,Suzhou215001,China;3.DepartmentofChemistryandChemicalEngineering,SuzhouUniversity,Suzhou215123,China)

[Abstract]Objective:Tostudythephysical,magneticandtransportablepropertiesofUSPIOnanoparticlespreparedinourlaboratoryandexploreitspossibilityforusingasnegativecontrastagentsinMRI.Methods:Theironoxidenanoparti-cleswasobtainedbymeansofco-precipitationone-stepmethod,itsinnercrystalstructurewasanalyzedbyX-raydiffrac-tion(XRD),itssurfacestructurewasanalyzedbyFouriertransforminfrared(FT-IR),itssizewasmeasuredbytransmissionelectronmicroscopy(TEM)anddynamicloserscatteringsystem,anditssusceptibilitywasmeasuredbyvibratingsamplemag-netometer(VSM).Theironcontentinbloodandvariousorganinrabbitsatdifferenttimewasmeasuredbyatomicabsorp-tionspectrometer,theenhancing-effectofliverandlymphafterinjectingsamplewasobservedbyMRI.Results:Thedi-ameterofdextran-coatedironoxidenanoparticleswas6-8nm,itsoveralldiameterwas33nm,theironcontentofsamplewas0.2mmol/L.Theseparticlespossedsomecharacteristicsofsuperparamagnetic,saturationmagneticintensitywas48.01emu/g.Thecirculationtimeofsampleinbloodplasmaofrabbitwaslong,itdistributedinsomeorgans,suchasspleen,liver,lung,heartandlymphwhichhadabundantofreticuloendothelialcells.ThesignalofT2-

weightedMRimagesofliverandlymphdecreasedremarkably.Conclusion:TheexperimentalconclusionshowsthesampleUSPIOcanbeusedasapromisingnegativeMRagentforvarioustypesofliver,spleenandlymphdiseasesdiagnosis.

USPIO;Physicalproperty;Magneticproperty;Transportableproperty;NegativecontrastagentsinMRI

随着科技的进一步发展，纳米生物材料被广泛研究并投入临床，其中超微超顺磁性氧化铁纳米粒（ultrasmallsuperpara-但该产品价格昂贵，国内市场难觅踪影，本实验采用化学共沉淀一步法制备USPIO，从物理、磁学性质、传递特性等方面进行研究，探讨其作为磁共振阴性对比剂应用于临床的可能性。magneticironoxide，西安瑞禧生物USPIO）作为一种新型的磁性纳米生物材料，常用于磁共振的阴性对比剂、示踪剂及靶向药物载体等，

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