尿路上皮及尿路上皮细胞牵张拉伸应力加载系统及文献,Urothelial & uroepithelial cells tension culture
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Urothelial & uroepithelial cells（Flexcell Fx-5000 cells TENSION CULTURE SYSTEM ）
23. Jerde TJ, Mellon WS, Bjorling DE, Nakada SY. Evaluation of urothelial stretch-induced cyclooxygenase-2 expression in novel human cell culture and porcine in vivo ureteral obstruction models. J Pharmacol Exp Ther 317(3):965-972, 2006.
24. Jerde TJ, Mellon WS, Bjorling DE, Checura CM, Owusu-Ofori K, Parrish JJ, Nakada SY. Stretch induction of cyclooxygenase-2 expression in human urothelial cells is calcium- and protein kinase C zeta-dependent. Mol Pharmacol 73(1):18-26, 2008. Erratum in: Mol Pharmacol 74(2):539, 2008.
25. Sun Y, Chai TC. Effects of dimethyl sulphoxide and heparin on stretch-activated ATP release by bladder urothelial cells from patients with interstitial cystitis. BJU Int 90(4):381-385, 2002.
26. Sun Y, Chai TC. Up-regulation of P2X3 receptor during stretch of bladder urothelial cells from patients with interstitial cystitis. J Urol 171(1):448-452, 2004.
27. Sun Y, Keay S, De Deyne PG, Chai TC. Augmented stretch activated adenosine triphosphate release from bladder uroepithelial cells in patients with interstitial cystitis. Journal of Urology 166(5):1951-1956, 2001.
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28. Sun Y, Keay S, DeDeyne P, Chai T. Stretch-activated release of adenosine triphosphate by bladder uroepithelia is augmented in interstitial cystitis [abstract]. Urology 57(6 Suppl 1):131, 2001.
29. Sun Y, MaLossi J, Jacobs SC, Chai TC. Effect of doxazosin on stretch-activated adenosine triphosphate release in bladder urothelial cells from patients with benign prostatic hyperplasia. Urology 60(2):351-356, 2002.
FX-5000T细胞牵张拉伸应力加载系统(Flexcell FX5000 Tension system)
1）该系统对二维、三维细胞和组织提供轴向和圆周应力加载；
2）基于柔性膜基底变形、受力均匀;
3）可实时观察细胞、组织在应力作用下的反应;
4）可有选择性地封阻对细胞的应力加载;
5）同时兼备多通道细胞压力加载功能;
6）与Flex Flow平行板流室配套，可以在牵拉细胞的同时施加流体切应力;
7）多达4通道，可4个不同程序同时运行，进行多个不同拉伸形变率对比实验；
8）同一程序中可以运行多种频率，多种振幅和多种波形；
9）更好地控制在超低或超高应力下的波形；
10）多种波形种类：静态波形、正旋波形、心动波形、三角波形、矩形以及各种特制波形；
11)电脑系统对牵张拉伸力加载周期、大小、频率、持续时间精确智能调控
应用范围：加载分析各种细胞在应力刺激下的生物化学反应:
例如：骨骼细胞、肺细胞、心肌细胞、血细胞、皮肤细胞、肌腱细胞、韧带细胞、软骨细胞和骨细胞、
肾膀胱细胞、平滑肌细胞/尿路上皮及尿路上皮细胞、眼上皮细胞、眼小梁组织细胞、肾小管上皮细胞、
肠上皮细胞、胃上皮细胞等细胞牵张拉伸力加载。
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