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艾美捷Aniracetam阿尼西坦解决方案
Aniracetam是一种促智安帕因, 表现出抗焦虑和神经保护活性.阿尼西坦作为AMPA受体的正变构调节剂,减缓受体失活;它还作用于 D2 受体、5-HT2A 受体和烟碱乙酰胆碱受体 (nAChRs),可能显示激动剂活性。Aniracetam在恐惧压力测试,升高加迷宫测试和社会互动测试中减少体内焦虑。此外,该化合物抑制 H2O2 诱导的长期增强和神经元活力缺陷.阿尼西坦在增强与中风和阿尔茨海默病相关的认知缺陷方面显示出一些临床益处。
艾美捷Aniracetam #LKT-A5326-25mg相关信息:
cas#:72432-10-1
纯度:≥98%
公式: C12H13NO3
配方重量:219.24
化学名称:1-(4-甲氧基苯甲酰基)-2-吡咯烷酮
IUPAC名称:1-(4-甲氧基苯甲酰基)吡咯烷-2-酮
同义词:Ro-13-5057, 德拉加农, 萨普尔
熔点:121-122°C
溶解度:溶于氯仿和乙酸乙酯。微溶于乙醇。不溶于水。
外观:白色或几乎白色结晶粉末
Aniracetam文献参考:
Wang YF, Li CC, Cai JX. Aniracetam attenuates H2O2-induced deficiency of neuron viability, mitochondria potential and hippocampal long-term potentiation of mice in vitro. Neurosci Bull. 2006 Sep;22(5):274-80. PMID: 17690727.
Jin R, Clark S, Weeks AM, et al. Mechanism of positive allosteric modulators acting on AMPA receptors. J Neurosci. 2005 Sep 28;25(39):9027-36. PMID: 16192394.
Nakamura K. Aniracetam: its novel therapeutic potential in cerebral dysfunctional disorders based on recent pharmacological discoveries. CNS Drug Rev. 2002 Spring;8(1):70-89. PMID: 12070527.
Nakamura K, Kurasawa M. Anxiolytic effects of aniracetam in three different mouse models of anxiety and the underlying mechanism. Eur J Pharmacol. 2001 May 18;420(1):33-43. PMID: 11412837.
Ito I, Tanabe S, Kohda A, et al. Allosteric potentiation of quisqualate receptors by a nootropic drug aniracetam. J Physiol. 1990 May;424:533-43. PMID: 1975272.
来源:https://lktlabs.com/product/aniracetam
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艾美捷Anorexigenic Peptide解决方案
Anorexigenic Peptide对体内直接食物摄入显示出混合影响,并可能显示出厌食活性。这种肽抑制激素和胃分泌反应,减少胃泌素或其他胰腺激素的分泌,以响应喂养和类似的刺激。
艾美捷Anorexigenic Peptide #LKT-A5458-1mg相关信息:
cas#:69275-10-1
纯度:≥95%
公式:C13H17N5O5
配方重量:323.4
IUPAC名称:2-[(2S)-3-(4H-咪唑-4-基)-2-[[(2S)-5-氧代吡咯烷-2-羰基] 氨基]丙酰基]氨基]乙酸
溶解度:易溶于水。
外观:白色至类白色粉末
储存温度:-20°C
Description
This peptide shows mixed effects on direct food intake in vivo and may display anorexigenic activity. This peptide inhibits hormonal and gastric secretory responses, decreasing secretion of gastrin or other pancreatic hormones in response to feeding and similar stimuli.
Product Info
Cas No. 69275-10-1
Purity ≥95%
Formula C13H17N5O5
Formula Wt. 323.4
IUPAC Name 2-[[(2S)-3-(4H-imidazol-4-yl)-2-[[(2S)-5-oxopyrrolidine-2-carbonyl] amino]propanoyl]amino]acetic acid
Solubility Soluble in water.
Appearance White to off white powder
Aniracetam文献参考:
Blavet N, DeFeudis FV, Clostre F. Lack of effect of the peptide pyro-Glu-His-Gly-OH on food consumption in mice and rats. Gen Pharmacol. 1982;13(2):173-6. PMID: 6807743.
Coy D, Jaworek J, Konturek SJ, et al. Effects of anorexigenic peptide on gastric and pancreatic secretion. J Physiol. 1981 May;314:225-35. PMID: 7031225.
来源:https://www.amyjet.com/products/LKT-A5458-1mg.shtml
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艾美捷Ansamitocin P3安丝菌素P3解决方案
Ansamitocin P3通过结合微管蛋白诱导微管解聚;它具有免疫调节和抗癌活性。安萨霉素P3增加T细胞信号传导和抗原摄取,并降低体内调节性T细胞水平。
艾美捷Ansamitocin P3 #LKT-A5472-5mg相关信息:
cas#:66547-09-9
纯度:≥70%
公式:C32H43CIN2O9
配方重量:635.14
溶解度:10毫米二甲基二甲基苯甲酸
储存温度:-20°C
Description
Ansamitocin P3 induces microtubule depolymerization by binding tubulin; it exhibits immunomodulatory and anticancer activities. Ansamitocin P3 increases T cell signaling and antigen uptake and decreases regulatory T cell levels in vivo.
Product Info
Cas No. 66547-09-9
Purity ≥70%
Formula C32H43CIN2O9
Formula Wt. 635.14
Solubility 10mM DMSO
Ansamitocin P3文献参考:
Martin K, Müller P, Schreiner J, et al. The microtubule-depolymerizing agent ansamitocin P3 programs dendritic cells toward enhanced anti-tumor immunity. Cancer Immunol Immunother. 2014 Sep;63(9):925-38. PMID: 24906866.
Venghateri JB, Gupta TK, Verma PJ, et al. Ansamitocin P3 depolymerizes microtubules and induces apoptosis by binding to tubulin at the vinblastine site. PLoS One. 2013 Oct 4;8(10):e75182. PMID: 24124473.
来源:https://www.amyjet.com/products/LKT-A5458-1mg.shtml
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中英文说明丨艾美捷磷酸化-Tau(Thr 231)抗体
Description
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
Specifications
Target Protein Phospho-Tau (Thr231)
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application WB,ELISA
Recommended Dilution WB 1:500-1:2000
Concentration 1 mg/ml
Reactive Species Human,Mouse,Rat
Host Species Rabbit
Immunogen A synthesized peptide derived from human Tau around the phosphorylation site of Threonine 231
Specificity Phospho-Tau (Thr231) Antibody detects endogenous levels of Tau only when phosphorylated at Threonine 231
Purification The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Form Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt
Gene Name MAPT
Accession No. P10636
Alternate Names AI413597; AW045860; DDPAC; FLJ31424; FTDP 17; G protein beta1/gamma2 subunit interacting factor 1; MAPT; MAPTL; MGC134287; MGC138549; MGC156663; Microtubule associated protein tau; Microtubule associated protein tau isoform 4; Microtubule-associated protein tau; MSTD; Mtapt; MTBT1; MTBT2; Neurofibrillary tangle protein; Paired helical filament tau; Paired helical filament-tau; PHF tau; PHF-tau; PPND; PPP1R103; Protein phosphatase 1, regulatory subunit 103; pTau; RNPTAU; TAU; TAU_HUMAN; Tauopathy and respiratory failure, included;
促进微管组装和稳定性,并可能参与神经元极性的建立和维持。C末端结合轴突微管,而N末端结合神经质膜成分,这表明tau作为两者之间的连接蛋白起作用。轴突极性由中心体定义的细胞体结构域中的TAU/MAPT定位(在神经元细胞中)预先确定。短亚型允许细胞骨架的可塑性,而较长的亚型可以优先在其稳定中发挥作用。
艾美捷磷酸化-Tau(Thr 231)抗体#GBS-ITA0919-100u规格:
目标蛋白 磷酸Tau(Thr231)
克隆性 多克隆
储存/稳定性 -20°C/1 年
应用 WB,酶联免疫吸附法
推荐稀释度 WB 1:500-1:2000
浓度 1毫克/毫升
反应性物质 人,老鼠,大鼠
寄主物种 兔
免疫原 一种衍生自人Tau的合成肽,围绕苏氨酸231的磷酸化位点
特 异性 磷酸化-Tau抗体(Thr231)仅在苏氨酸231磷酸化时检测Tau的内源性水平
纯化 该抗体来自纯化的兔血清,通过磷酸化和非磷酸肽亲和柱上的顺序色谱进行亲和纯化。
形式 兔IgG在磷酸盐缓冲盐水中,pH 7.4,150mM NaCl,0.02%叠氮化钠和50%甘油。储存在-20°C.自收到之日起可稳定保存12个月
基因名称 马普特
藏品编号 P10636
细胞通路/类别 一抗多克隆抗体
蛋白质分子量 78kDa
用法 仅供研究使用!不适用于诊断或治疗程序
来源:https://www.amyjet.com/products/GBS-ITA0919-100u.shtml
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中英文说明丨艾美捷HPV16 E7抗体 (10-7988)
Synonyms:
Monoclonal Papilloma Virus antibody, Anti-Papilloma Virus antibody, Human Papilloma E7, Human Papillomavirus Antibody, Type 16 Papilloma Virus antibody, Human Papilloma E 7 antibody, Human Papilloma E 7, Human Papilloma E-7, Human Papilloma E-7 antibody
Applications:
ELISA, Immunoassays
Immunogen:
Human Papilloma Virus Type 16 antibody was raised in mouse using HPV oncoprotein E7, type 16 as the immunogen.
Assay Information:
10-7988 can be used in a sandwich immunoassay as a coating antibody in conjunction with 10-7989 as the conjugate antibody
SPECIFICATIONS
Host Mouse
Form & Buffer Supplied in PBS, pH 7.2, 0.1 % sodium azide (NaN3)
Method of Purification Human Papilloma Virus Type 16 antibody was purified by Protein G chromatography.
Isotype IgG2b
Clone M18612HP5
Storage Store at 4 Deg C
Biohazard Information This product is sold as an antibody preparation for research use only. Standard Laboratory Practices should be followed when handling this material. Contains sodium azide (0.1 %) as preservative. Although the amount of sodium azide is very small appropria
Biological Significance:
Infection with specific types of human Papillomavirus (HPV) has been associated with an increased risk of developing cervical neoplasia. HPV types 6 and 11 have been associated with relatively benign diseases such as genital warts but types 16 and 18 are
艾美捷HPV16 E7抗体#10-7988
小鼠单克隆HPV16抗体概述:
同义词
单克隆瘤病毒抗体、抗瘤病毒抗体、人瘤E7、人瘤病毒抗体、16型瘤病毒抗体、人瘤E 7抗体、人瘤E 7、人瘤E-7、人瘤E-7抗体
应用
酶联免疫药,免疫分析
免疫原
使用HPV癌蛋白E16,7型作为免疫原在小鼠中培养人瘤病毒16型抗体。
检测信息
10-7988 可作为包被抗体与 10-7989 作为偶联抗体联合用于夹心免疫测定
HPV16 E7抗体#10-7988规格:
宿主
鼠
形式和缓冲区
以 PBS、pH 7.2、0.1% 叠氮化钠 (NaN3) 形式提供
纯化方法
人瘤病毒16型抗体经蛋白G色谱纯化。
同种型
免疫球蛋白G2b
克隆
货号 M18612HP5
存储与安全
存储
储存在 4 摄氏度
生物危害信息
本品仅供研究使用。处理这种材料时应遵循标准实验室规范。含有叠氮化钠(0.1%)作为防腐剂。虽然叠氮化钠的量非常少
HPV16 E7抗体的生物学意义:
感染特定类型的人瘤病毒 (HPV) 与发生宫颈瘤变的风险增加有关。HPV 6型和11型与相对良性疾病有关,如生殖器疣,但16型和18型
来源;https://www.amyjet.com/products/10-7988.shtml
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中英文说明丨艾美捷AffiniPure兔抗人血清伊加,α链特异性
Based on immunoelectrophoresis and/or ELISA, the antibody reacts with the heavy chain of human IgA but not with human IgG or IgM. No antibody was detected against non-immunoglobulin serum proteins. The antibody may cross-react with IgA from other species.
Whole IgG antibodies are isolated as intact molecules from antisera by immunoaffinity chromatography. They have an Fc portion and two antigen binding Fab portions joined together by disulfide bonds and therefore they are divalent. The average molecular weight is reported to be about 160 kDa. The whole IgG form of antibodies is suitable for the majority of immunodetection procedures and is the most cost effective.
Usage
Physical State: Sterile-filtered liquid
Storage: Store at 2-8°C under sterile conditions. Prepare working dilution on day of use.
Expiration date: one year from date of receipt. The expiration date may be extended if test results are acceptable for the intended use.
Purity: The antibody was purified from antisera by immunoaffinity chromatography using antigens coupled to agarose beads.
Buffer: 0.01M Sodium Phosphate, 0.25M NaCl, pH 7.6
Preservative: None
Suggested Working Concentration or Dilution Range:
10-20 µg / ml
Dilution factors are presented in the form of a range because the optimal dilution is a function of many factors, such as antigen density, permeability, etc. The actual dilution used must be determined empirically.
基于免疫电泳和/或ELISA抗体,抗体与人IgA的重链反应,但不与人IgG或IgM反应。未检测到针对非免疫球蛋白血清蛋白的抗体。该抗体可能与其他物种的IgA发生交叉反应。
通过免疫亲和色谱法从抗血清中分离出完整的 IgG 抗体作为完整分子。它们有一个Fc部分和两个抗原结合Fab部分通过二硫键连接在一起,因此它们是二价的。据报道,平均分子量约为160kDa。整个IgG形式的抗体适用于大多数免疫检测程序,并且非常具有成本效益。
艾美捷AffiniPure兔抗人血清伊加,α链特异性#309-005-011用法:
物理状态:无菌过滤液
存储: 在无菌条件下储存在2-8°C。使用当天准备工作稀释液。
有效期:自收到之日起一年。如果测试结果可以接受预期用途,则有效期可以延长。
纯度:使用与琼脂糖珠偶联的抗原通过免疫亲和色谱法从抗血清中纯化抗体。
缓冲液:0.01M磷酸钠,0.25M氯化钠,pH 7.6
防腐剂:无
建议工作浓度或稀释范围:
10-20μg/ ml
稀释因子以范围的形式呈现,因为最佳稀释度是许多因素的函数,例如抗原密度,渗透性等。实际使用的稀释度必须根据经验确定。
AffiniPure兔抗人血清伊加,α链特异性#309-005-011
目标: 人类
宿主:兔
抗体形式:全 IgG 特异性:血清 IgA,α链特异性
偶联物:非偶联
产品类别:全 IgG
亲和纯化抗体
克隆性:多克隆
RRID:AB_2339627
来源;https://www.amyjet.com/products/309-005-011.shtml
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Covalab丨艾美捷纤维蛋白原Α链抗体解决方案
Covalab纤维蛋白原Α链抗体:
纤维蛋白原α链
基因名称:fga
Covalab丨艾美捷纤维蛋白原Α链抗体详细信息:
ID Covalab PAB0999-P
产品类型 一抗
克隆性 多克隆抗体
在 兔
免疫原 源自斑马鱼纤维蛋白原α链的合成肽
活叉反应 与斑马鱼纤维蛋白原α链反应
物种 兹菲
标签 没有
形式 纯化(蛋白A)
防腐剂 没有
存储说明 冻干粉末在 -2°C 下可稳定保存至少 20 年。 将重组抗体储存在 +4°C。 长时间在-20°C下等分储存。 抗体自收到之日起保证6个月。
目标 纤维蛋白原α链
统一认证 Q6DHS2
应用 ELISA,WB
工作稀释液 最佳稀释度应由最终用户确定。
以下仅供参考:WB 1:100 - 1:2000
Covalab 纤维蛋白原Α链抗体文献参考:
* RJ Fish et al. Int J Mol Sci. 2021 Jan 11:22(2):E655 (Zfi, WB)
* C Freire et al. Blood Adv. 2020 Nov 10:4(21):5480-5491 (Zfi, WB)
* C. Freire Sanz, Hemostasis and thrombosis in zebrafish models of human congenital fibrinogen disorders, Ph.D. Thesis, Sept 2020 (Zfi, WB)
Covalab专注于抗体研发领域,涵盖抗体和试剂盒。拥有多种针对流行和罕见靶标的一抗,涉及多种应用领域,如癌症,表观遗传学,细胞信号传导,心血管等疾病的生物标志物,神经系统,离子通道,微生物学,病毒学等。还有特色的应用于模式动物斑马鱼的抗体。此外还有各种ELISA试剂盒,ELISPot试剂盒,FluoroSpot试剂盒等。艾美捷科技是Covalab的中国代理商,为科研工作者提供优质的产品与服务。
来源:https://www.amyjet.com/brand/Covalab.shtml
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Covalab丨艾美捷耐甲氧西林金黄色葡萄球菌抗体
Covalab 耐甲氧西林金黄色葡萄球菌抗体背景:
耐甲氧西林金黄色葡萄球菌是临床上常见的毒性较强的细菌,自从上世纪40年代青霉素问世后,金黄色葡萄球菌引起的感染性疾病受到较大的控制。但随着青霉素的广泛使用,有些金黄色葡萄球菌产生青霉素酶,能水解β-内酰胺环,表现为对青霉素的耐药。科学家研究出一种新的能耐青霉素酶的半合成青霉素,即甲氧西林(methicillin)。
Covalab丨艾美捷纤维蛋白原Α链抗体详细信息:
ID Covalab MAB60600
产品类型 一抗
克隆性 单克隆抗体
克隆 蚂蚁-198
同种型 免疫球蛋白G1
在 鼠
免疫原 凝胶纯化的MRSA蛋白。
活叉反应 与耐甲氧西林金黄色葡萄球菌表达的MRSA基因产物发生反应。
物种 北克
标签 没有
形式 纯化
防腐剂 没有
存储说明 这种冻干产品在4°C下可稳定保存两年。 复溶后,将等分试样储存在-20°C。
目标 耐甲氧西林金黄色葡萄球菌 (MRSA)
应用 艾丽莎,WB
工作稀释液 最佳稀释度应由最终用户确定。
以下仅是指南:
ELISA(1:5000 直接针对纯化的 MRSA 蛋白或 MRSA 阳性金黄色葡萄球菌裂解物的 ELISA)WB (1:2000)
Covalab专注于抗体研发领域,涵盖抗体和试剂盒。拥有多种针对流行和罕见靶标的一抗,涉及多种应用领域,如癌症,表观遗传学,细胞信号传导,心血管等疾病的生物标志物,神经系统,离子通道,微生物学,病毒学等。还有特色的应用于模式动物斑马鱼的抗体。此外还有各种ELISA试剂盒,ELISPot试剂盒,FluoroSpot试剂盒等。艾美捷科技是Covalab的中国代理商,为科研工作者提供优质的产品与服务。
来源:https://www.amyjet.com/brand/Covalab.shtml