来宝网 2013/4/11点击1751次
■ 产品介绍
手性有机小分子催化剂因具有反应条件温和、环境友好、催化剂易于回收利用、符合绿色化学的要求等优点，成为近年来不对称催化领域发展起来的一个研究热点。其中，手性双胍类有机小分子催化剂可用于不对称的Michael 加成反应、Mannich反应、脱羧反应、胺化反应及炔烃的手性连烯重排反应等等，并可实现良好收率和立体选择性，充分显示了手性双胍小分子催化剂在不对称反应中的巨大潜力。
产品性质稳定，易于储存；
反应条件温和，反应易于操作；
反应底物范围广，可催化多种反应类型；
催化剂无金属残留，可用于制药或香精香料生产；
高度优势的产品价格，齐全的包装规格，国内现货量充足。
■ 手性五元二环胍
|
产品编号
|
产品名称
|
结构式
|
CAS
|
包装
|
|
(2S,6S)-双苄基五元二环胍
(2S,6S)-2,6-Di-benzyl-2,3,5,6-tetrahydro-1H-imidazo[1,2-a]imidazole, 98%
|
 |
100 mg
500 mg
|
||
|
(2S,6S)-双叔丁基五元二环胍
(2S,6S)-2,6-Di-tert-butyl-2,3,5,6-tetrahydro-1H-imidazo[1,2-a]imidazole, 98%
|
 |
100 mg
500 mg
|
■ 产品技术应用
1. Biomimetic Enantioselective Decarboxylative Reactions catalysed by chiral bicyclic guanidine;
2. Bicyclic guanidine-catalyzed enantioselective Phospha-Michael reaction;
3. Bicyclic Guanidine-Catalyzed Direct Asymmetric Allylic Addition of N-Aryl Alkylidene-Succinimides;
4. Enantioselective Protonation Catalyzed by a Chiral Bicyclic Guanidine;
5. Chiral bicyclic guanidine catalysed Mannich reaction;
6. Enantiodivergent and g-Selective Asymmetric Allylic Amination;
7. Enantioselective Synthesis of Chiral Allenoates by Guanidine-Catalyzed Isomerization of 3-Alkynoates.
Ref.:
[1]. Chem. Eur. J. 2011, 17, 8363 - 8370;
[2]. Chemical Commununications, 2007, 47, 5058-5060;
[3]. Chem. Eur. J. 2010, 16, 12534 - 12537;
[4]. Angew. Chem. Int. Ed. 2008, 47, 5641 - 5645;
[5]. a). Chem. Eur. J. 2011, 17, 3571 - 3574; b). Chem. Eur. J. 2010, 16, 779 -782;
[6]. Angew. Chem. Int. Ed. 2012, 51, 1 - 6;
[7]. J. Am. Chem. Soc. 2009, 131, 7212 - 7213.
■ 其它手性有机小分子催化剂
|
产品编号
|
产品名称
|
结构式
|
CAS
|
包装
|
|
(S)-(+)-2-(苯胺甲基)吡咯烷
(S)-(+)-2-(Anilinomethyl)pyrrolidine, 97%
|
 |
250 mg
1 g
|
||
|
L-氮杂环丁烷-2-羧酸
L-Azetidine-2-carboxylic acid, 98%
|
 |
50 mg
250 mg
|
||
|
(S)-α,α-双[3,5-双(三氟甲基)苯基]-2-吡咯烷甲醇三甲基硅基醚
(S)-α,α-Bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanol trimethylsilyl ether, 95%
|
 |
250 mg
1 g
|
||
|
α,α-二苯基-N-甲基-D-脯氨醇
α,α-Diphenyl-N-methyl-D-prolinol, 98% [ee: 98%]
|
 |
250 mg
1 g
|
||
|
α,α-二苯基-N-甲基-L-脯氨醇
α,α-Diphenyl-N-methyl-L-prolinol, 97%
|
 |
250 mg
1 g
5 g
|
||
|
(R)-(+)-2-(二苯基甲基)吡咯烷
(R)-(+)-2-(Diphenylmethyl)pyrrolidine, 97%
|
 |
250 mg
1 g
5 g
|
||
|
(S)-2-二苯基甲基吡咯烷
(S)-2-Diphenylmethylpyrrolidine, 97%
|
 |
250 mg
1 g
|
||
|
(R)-(+)-α,α-二苯基脯氨醇
(R)-(+)-α,α-Diphenyl-2-pyrrolidinemethanol, 98%
|
 |
250 mg
1 g
5 g
|
||
|
(S)-(-)-α,α-二苯基-2-脯氨醇
(S)-(-)-α,α-Diphenyl-2-pyrrolidinemethanol, 98%
|
 |
500 mg
1 g
5 g
|
||
|
α-甲基-L-脯氨酸
α-Methyl-L-proline, 98%
|
 |
250 mg
1 g
5 g
|
||
|
L-脯氨酸
L-Proline, 99%
|
 |
25 g
100 g
500 g
|
||
|
(S)-(+)-1-(2-吡咯烷甲基)吡咯烷
(S)-(+)-1-(2-Pyrrolidinylmethyl)pyrrolidine, 98%
|
 |
250 mg
1 g
|
||
|
N-[(2S)-2-吡咯烷甲基]-三氟甲磺酰胺
N-[(2S)-2-Pyrrolidinylmethyl]-trifluoromethanesulfonamide, 98.5% [ee:98.5%]
|
 |
100 mg
500 mg
|
||
|
(S)-(-)-5-(吡咯烷-2-基)-1H-四唑
(S)-(-)-5-(2-Pyrrolidinyl)-1H-tetrazole, 98%
|
 |
100 mg
500 mg
|
||
|
L-4-羧基噻唑烷
L-4-Thiazolidinecarboxylic acid, 98%
|
 |
5 g
25 g
100 g
|
