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Microwave irradiation dramatically increases the isolated yield of an alkyne cyclotrimerization step when compared to conventional heating methods. The flexibility of being able to perform a reaction in either an open or sealed vessel format provides the ability to add all reagents at the start of the reaction to take advantage of a high temperature/high pressure environment or add reagents during the reaction, reducing byproduct formation.

        与传统加热方法相比，微波辐射大大增加了alkyne cyclotrimerization分离产量。在敞口和密封的条件下，均可进行反应。在反应开始前，可添加所有试剂反应试剂，在高温高压环境或添加试剂反应时，减少副产物的形成。