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INTRODUCTION

In the development of antibodies directed against specific peptide sequences, T-helper epitopes are often tagged onto the peptide sequence to aid in the stimulation of the immune response. One such sequence is the universal Pan HLA DR-binding epitope (PADRE). Synthesis of the PADRE peptide has proven to be difficult. The Accent Microwave Peptide Cleavage System allows for rapid microcleavage during peptide synthesis for analysis, providing quick determination of coupling efficiency.

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